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New page: left|200px<br /><applet load="1jnp" size="450" color="white" frame="true" align="right" spinBox="true" caption="1jnp, resolution 2.50Å" /> '''Crystal Structure of...
 
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[[Image:1jnp.jpg|left|200px]]<br /><applet load="1jnp" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1jnp, resolution 2.50&Aring;" />
'''Crystal Structure of Murine Tcl1 at 2.5 Resolution'''<br />


==Overview==
==Crystal Structure of Murine Tcl1 at 2.5 Resolution==
Tcl1 and Mtcp1, members of the Tcl1 family, are implicated in T-cell, prolymphocytic leukemia. The crystal structure of a dimer of murine Tcl1, has been determined at 2.5 A resolution with an R factor of 0.225. Murine, Tcl1, human Tcl1 and Mtcp1 share very similar subunit structures, with RMS, differences of 0.6 and 1.4 A for C(alpha) atoms, respectively, while the, sequences share 50 and 36% identity, respectively. These structures fold, into an eight-stranded beta-barrel of unique topology and high internal, symmetry of 1.1-1.3 A for the two halves of human and murine Tcl1 and 1.7, A for Mtcp1, despite the low 12-13% sequence identity. The molecular, surfaces of all three structures showed a common planar region which is, likely to be involved in protein-protein interactions.
<StructureSection load='1jnp' size='340' side='right'caption='[[1jnp]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[1jnp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JNP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JNP FirstGlance]. <br>
1JNP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1JNP OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jnp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jnp OCA], [https://pdbe.org/1jnp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jnp RCSB], [https://www.ebi.ac.uk/pdbsum/1jnp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jnp ProSAT]</span></td></tr>
==Reference==
</table>
Structure of murine Tcl1 at 2.5 A resolution and implications for the TCL oncogene family., Petock JM, Torshin IY, Wang YF, Du Bois GC, Croce CM, Harrison RW, Weber IT, Acta Crystallogr D Biol Crystallogr. 2001 Nov;57(Pt 11):1545-51. Epub 2001, Oct 25. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11679718 11679718]
== Function ==
[https://www.uniprot.org/uniprot/TCL1A_MOUSE TCL1A_MOUSE] Enhances the phosphorylation and activation of AKT1 and AKT2. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jn/1jnp_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jnp ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Single protein]]
[[Category: Croce CM]]
[[Category: Croce, C.M.]]
[[Category: DuBois GC]]
[[Category: DuBois, G.C.]]
[[Category: Harrison RW]]
[[Category: Harrison, R.W.]]
[[Category: Petock JM]]
[[Category: Petock, J.M.]]
[[Category: Torshin IY]]
[[Category: Torshin, I.Y.]]
[[Category: Wang YF]]
[[Category: Wang, Y.F.]]
[[Category: Weber IT]]
[[Category: Weber, I.T.]]
[[Category: beta barrel]]
[[Category: dimer]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 18:24:31 2007''

Latest revision as of 07:40, 7 February 2024

Crystal Structure of Murine Tcl1 at 2.5 Resolution

1jnp, resolution 2.50Å

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