2a2c: Difference between revisions

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{{Seed}}
[[Image:2a2c.png|left|200px]]


<!--
==x-ray structure of human N-acetyl galactosamine kinase complexed with Mg-ADP and N-acetyl galactosamine 1-phosphate==
The line below this paragraph, containing "STRUCTURE_2a2c", creates the "Structure Box" on the page.
<StructureSection load='2a2c' size='340' side='right'caption='[[2a2c]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2a2c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A2C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A2C FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NG1:N-ACETYL-ALPHA-D-GALACTOSAMINE+1-PHOSPHATE'>NG1</scene></td></tr>
{{STRUCTURE_2a2c| PDB=2a2c |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a2c OCA], [https://pdbe.org/2a2c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a2c RCSB], [https://www.ebi.ac.uk/pdbsum/2a2c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a2c ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GALK2_HUMAN GALK2_HUMAN] Acts on GalNAc. Also acts as a galactokinase when galactose is present at high concentrations. May be involved in a salvage pathway for the reutilization of free GalNAc derived from the degradation of complex carbohydrates.<ref>PMID:8798585</ref> <ref>PMID:16006554</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a2/2a2c_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2a2c ConSurf].
<div style="clear:both"></div>


===x-ray structure of human N-acetyl galactosamine kinase complexed with Mg-ADP and N-acetyl galactosamine 1-phosphate===
==See Also==
 
*[[Cyclophilin 3D structures|Cyclophilin 3D structures]]
 
== References ==
<!--
<references/>
The line below this paragraph, {{ABSTRACT_PUBMED_16006554}}, adds the Publication Abstract to the page
__TOC__
(as it appears on PubMed at http://www.pubmed.gov), where 16006554 is the PubMed ID number.
</StructureSection>
-->
{{ABSTRACT_PUBMED_16006554}}
 
==About this Structure==
2A2C is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A2C OCA].
 
==Reference==
The molecular architecture of human N-acetylgalactosamine kinase., Thoden JB, Holden HM, J Biol Chem. 2005 Sep 23;280(38):32784-91. Epub 2005 Jul 8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16006554 16006554]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Holden, H M.]]
[[Category: Holden HM]]
[[Category: Thoden, J B.]]
[[Category: Thoden JB]]
[[Category: Galactokinase]]
[[Category: Kinase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:21:27 2008''

Latest revision as of 09:10, 14 February 2024

x-ray structure of human N-acetyl galactosamine kinase complexed with Mg-ADP and N-acetyl galactosamine 1-phosphate

2a2c, resolution 1.65Å

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