1oro: Difference between revisions

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{{Seed}}
[[Image:1oro.png|left|200px]]


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==A FLEXIBLE LOOP AT THE DIMER INTERFACE IS A PART OF THE ACTIVE SITE OF THE ADJACENT MONOMER OF ESCHERICHIA COLI OROTATE PHOSPHORIBOSYLTRANSFERASE==
The line below this paragraph, containing "STRUCTURE_1oro", creates the "Structure Box" on the page.
<StructureSection load='1oro' size='340' side='right'caption='[[1oro]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1oro]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ORO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ORO FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_1oro| PDB=1oro |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oro OCA], [https://pdbe.org/1oro PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oro RCSB], [https://www.ebi.ac.uk/pdbsum/1oro PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oro ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PYRE_ECOLI PYRE_ECOLI] Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity).<ref>PMID:8620002</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/or/1oro_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1oro ConSurf].
<div style="clear:both"></div>


===A FLEXIBLE LOOP AT THE DIMER INTERFACE IS A PART OF THE ACTIVE SITE OF THE ADJACENT MONOMER OF ESCHERICHIA COLI OROTATE PHOSPHORIBOSYLTRANSFERASE===
==See Also==
 
*[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]]
 
== References ==
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<references/>
The line below this paragraph, {{ABSTRACT_PUBMED_8620002}}, adds the Publication Abstract to the page
__TOC__
(as it appears on PubMed at http://www.pubmed.gov), where 8620002 is the PubMed ID number.
</StructureSection>
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{{ABSTRACT_PUBMED_8620002}}
 
==About this Structure==
1ORO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ORO OCA].
 
==Reference==
A flexible loop at the dimer interface is a part of the active site of the adjacent monomer of Escherichia coli orotate phosphoribosyltransferase., Henriksen A, Aghajari N, Jensen KF, Gajhede M, Biochemistry. 1996 Mar 26;35(12):3803-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8620002 8620002]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Orotate phosphoribosyltransferase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Aghajari N]]
[[Category: Aghajari, N.]]
[[Category: Gajhede M]]
[[Category: Gajhede, M.]]
[[Category: Henriksen A]]
[[Category: Henriksen, A.]]
[[Category: Jensen KF]]
[[Category: Jensen, K F.]]
[[Category: Inhibitor-enzyme complex]]
[[Category: Phosphoribosyltransferase]]
[[Category: Pyrimidine nucleotide biosynthesis]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:26:42 2008''
Retrieved from "https://proteopedia.org/1oro"