2h8p: Difference between revisions

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{{Seed}}
[[Image:2h8p.png|left|200px]]


<!--
==Structure of a K channel with an amide to ester substitution in the selectivity filter==
The line below this paragraph, containing "STRUCTURE_2h8p", creates the "Structure Box" on the page.
<StructureSection load='2h8p' size='340' side='right'caption='[[2h8p]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2h8p]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Streptomyces_lividans Streptomyces lividans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H8P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2H8P FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B3H:(2S)-2-(BUTYRYLOXY)-3-HYDROXYPROPYL+NONANOATE'>B3H</scene>, <scene name='pdbligand=GOA:GLYCOLIC+ACID'>GOA</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
{{STRUCTURE_2h8p| PDB=2h8p |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2h8p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h8p OCA], [https://pdbe.org/2h8p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2h8p RCSB], [https://www.ebi.ac.uk/pdbsum/2h8p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2h8p ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q569B4_RAT Q569B4_RAT]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h8/2h8p_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2h8p ConSurf].
<div style="clear:both"></div>


===Structure of a K channel with an amide to ester substitution in the selectivity filter===
==See Also==
 
*[[Antibody 3D structures|Antibody 3D structures]]
 
*[[Potassium channel 3D structures|Potassium channel 3D structures]]
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*[[3D structures of non-human antibody|3D structures of non-human antibody]]
The line below this paragraph, {{ABSTRACT_PUBMED_16939283}}, adds the Publication Abstract to the page
__TOC__
(as it appears on PubMed at http://www.pubmed.gov), where 16939283 is the PubMed ID number.
</StructureSection>
-->
[[Category: Large Structures]]
{{ABSTRACT_PUBMED_16939283}}
 
==About this Structure==
2H8P is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H8P OCA].
 
==Reference==
Structural and functional consequences of an amide-to-ester substitution in the selectivity filter of a potassium channel., Valiyaveetil FI, Sekedat M, MacKinnon R, Muir TW, J Am Chem Soc. 2006 Sep 6;128(35):11591-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16939283 16939283]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Single protein]]
[[Category: Streptomyces lividans]]
[[Category: MacKinnon, R.]]
[[Category: MacKinnon R]]
[[Category: Muir, T W.]]
[[Category: Muir TW]]
[[Category: Valiyaveetil, F I.]]
[[Category: Valiyaveetil FI]]
[[Category: Channel]]
[[Category: Ester]]
[[Category: Semi-synthetic]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:28:34 2008''
Retrieved from "https://proteopedia.org/2h8p"