1x81: Difference between revisions

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{{Seed}}
[[Image:1x81.png|left|200px]]


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==Farnesyl transferase structure of Jansen compound==
The line below this paragraph, containing "STRUCTURE_1x81", creates the "Structure Box" on the page.
<StructureSection load='1x81' size='340' side='right'caption='[[1x81]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1x81]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X81 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X81 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JAN:6-[(S)-AMINO(4-CHLOROPHENYL)(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-4-(3-CHLOROPHENYL)-1-METHYLQUINOLIN-2(1H)-ONE'>JAN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_1x81| PDB=1x81 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x81 OCA], [https://pdbe.org/1x81 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x81 RCSB], [https://www.ebi.ac.uk/pdbsum/1x81 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x81 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FNTA_RAT FNTA_RAT] Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate. Through RAC1 prenylation and activation may positively regulate neuromuscular junction development downstream of MUSK (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x8/1x81_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1x81 ConSurf].
<div style="clear:both"></div>


===Farnesyl transferase structure of Jansen compound===
==See Also==
 
*[[Farnesyltransferase 3D structures|Farnesyltransferase 3D structures]]
 
__TOC__
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_15454228}}, adds the Publication Abstract to the page
[[Category: Large Structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 15454228 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15454228}}
 
==About this Structure==
1X81 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X81 OCA].
 
==Reference==
Design, synthesis, and activity of 4-quinolone and pyridone compounds as nonthiol-containing farnesyltransferase inhibitors., Li Q, Claiborne A, Li T, Hasvold L, Stoll VS, Muchmore S, Jakob CG, Gu W, Cohen J, Hutchins C, Frost D, Rosenberg SH, Sham HL, Bioorg Med Chem Lett. 2004 Nov 1;14(21):5367-70. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15454228 15454228]
[[Category: Protein complex]]
[[Category: Protein farnesyltransferase]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Claiborne, A.]]
[[Category: Claiborne A]]
[[Category: Cohen, J.]]
[[Category: Cohen J]]
[[Category: Frost, D.]]
[[Category: Frost D]]
[[Category: Gu, W.]]
[[Category: Gu W]]
[[Category: Hasvold, L.]]
[[Category: Hasvold L]]
[[Category: Hutchins, C.]]
[[Category: Hutchins C]]
[[Category: Jakob, C G.]]
[[Category: Jakob CG]]
[[Category: Li, Q.]]
[[Category: Li Q]]
[[Category: Li, T.]]
[[Category: Li T]]
[[Category: Muchmore, S.]]
[[Category: Muchmore S]]
[[Category: Rosenberg, S H.]]
[[Category: Rosenberg SH]]
[[Category: Sham, H L.]]
[[Category: Sham HL]]
[[Category: Stoll, V S.]]
[[Category: Stoll VS]]
[[Category: Fanesyltransferase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:56:26 2008''

Latest revision as of 08:48, 14 February 2024

Farnesyl transferase structure of Jansen compound

1x81, resolution 3.50Å

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