1qqa: Difference between revisions

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{{Seed}}
[[Image:1qqa.png|left|200px]]


<!--
==PURINE REPRESSOR MUTANT-HYPOXANTHINE-PALINDROMIC OPERATOR COMPLEX==
The line below this paragraph, containing "STRUCTURE_1qqa", creates the "Structure Box" on the page.
<StructureSection load='1qqa' size='340' side='right'caption='[[1qqa]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1qqa]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QQA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QQA FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HPA:HYPOXANTHINE'>HPA</scene></td></tr>
{{STRUCTURE_1qqa| PDB=1qqa |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qqa OCA], [https://pdbe.org/1qqa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qqa RCSB], [https://www.ebi.ac.uk/pdbsum/1qqa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qqa ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PURR_ECOLI PURR_ECOLI] Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. In addition, it participates in the regulation or coregulation of genes involved in de novo pyrimidine nucleotide biosynthesis, salvage and uptake (pyrC, pyrD, carAB and codBA), and of several genes encoding enzymes necessary for nucleotide and polyamine biosynthesis (prsA, glyA, gcvTHP, speA, glnB). Binds to a 16-bp palindromic sequence located within the promoter region of pur regulon genes. The consensus binding sequence is 5'-ACGCAAACGTTTTCNT-3'. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression.<ref>PMID:2404765</ref> <ref>PMID:2211500</ref> <ref>PMID:1400170</ref> <ref>PMID:14741201</ref>  
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qq/1qqa_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qqa ConSurf].
<div style="clear:both"></div>


===PURINE REPRESSOR MUTANT-HYPOXANTHINE-PALINDROMIC OPERATOR COMPLEX===
==See Also==
 
*[[Purine repressor|Purine repressor]]
 
== References ==
<!--
<references/>
The line below this paragraph, {{ABSTRACT_PUBMED_10438625}}, adds the Publication Abstract to the page
__TOC__
(as it appears on PubMed at http://www.pubmed.gov), where 10438625 is the PubMed ID number.
</StructureSection>
-->
{{ABSTRACT_PUBMED_10438625}}
 
==About this Structure==
1QQA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QQA OCA].
 
==Reference==
The role of lysine 55 in determining the specificity of the purine repressor for its operators through minor groove interactions., Glasfeld A, Koehler AN, Schumacher MA, Brennan RG, J Mol Biol. 1999 Aug 13;291(2):347-61. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10438625 10438625]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Brennan, R G.]]
[[Category: Brennan RG]]
[[Category: Glasfeld, A.]]
[[Category: Glasfeld A]]
[[Category: Koehler, A N.]]
[[Category: Koehler AN]]
[[Category: Schumacher, M A.]]
[[Category: Schumacher MA]]
[[Category: Dna-binding]]
[[Category: Purine biosynthesis]]
[[Category: Repressor]]
[[Category: Transcription regulation]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:13:36 2008''

Latest revision as of 08:16, 14 February 2024

PURINE REPRESSOR MUTANT-HYPOXANTHINE-PALINDROMIC OPERATOR COMPLEX

1qqa, resolution 3.00Å

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