1k4e: Difference between revisions

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New page: left|200px<br /><applet load="1k4e" size="450" color="white" frame="true" align="right" spinBox="true" caption="1k4e, resolution 2.00Å" /> '''CRYSTAL STRUCTURE OF...
 
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[[Image:1k4e.jpg|left|200px]]<br /><applet load="1k4e" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1k4e, resolution 2.00&Aring;" />
'''CRYSTAL STRUCTURE OF THE CLASS D BETA-LACTAMASES OXA-10 DETERMINED BY MAD PHASING WITH SELENOMETHIONINE'''<br />


==About this Structure==
==CRYSTAL STRUCTURE OF THE CLASS D BETA-LACTAMASES OXA-10 DETERMINED BY MAD PHASING WITH SELENOMETHIONINE==
1K4E is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1K4E OCA].  
<StructureSection load='1k4e' size='340' side='right'caption='[[1k4e]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
[[Category: Beta-lactamase]]
== Structural highlights ==
<table><tr><td colspan='2'>[[1k4e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K4E FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k4e OCA], [https://pdbe.org/1k4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k4e RCSB], [https://www.ebi.ac.uk/pdbsum/1k4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k4e ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BLO10_PSEAI BLO10_PSEAI] Hydrolyzes both carbenicillin and oxacillin.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k4/1k4e_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k4e ConSurf].
<div style="clear:both"></div>
 
==See Also==
*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Single protein]]
[[Category: Bouillene F]]
[[Category: Bouillene, F.]]
[[Category: Charlier P]]
[[Category: Charlier, P.]]
[[Category: Fonze E]]
[[Category: Fonze, E.]]
[[Category: Frere JM]]
[[Category: Frere, J.M.]]
[[Category: Kerff F]]
[[Category: Kerff, F.]]
[[Category: SO4]]
[[Category: beta-lactamase]]
[[Category: carbamylated lysine]]
[[Category: hydrolase]]
[[Category: mad phasing]]
[[Category: selenomethionine]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 18:50:53 2007''

Latest revision as of 09:42, 21 December 2022

CRYSTAL STRUCTURE OF THE CLASS D BETA-LACTAMASES OXA-10 DETERMINED BY MAD PHASING WITH SELENOMETHIONINE

1k4e, resolution 2.00Å

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