1osj: Difference between revisions

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{{Seed}}
[[Image:1osj.png|left|200px]]


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==STRUCTURE OF 3-ISOPROPYLMALATE DEHYDROGENASE==
The line below this paragraph, containing "STRUCTURE_1osj", creates the "Structure Box" on the page.
<StructureSection load='1osj' size='340' side='right'caption='[[1osj]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1osj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OSJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OSJ FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1osj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1osj OCA], [https://pdbe.org/1osj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1osj RCSB], [https://www.ebi.ac.uk/pdbsum/1osj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1osj ProSAT]</span></td></tr>
{{STRUCTURE_1osj| PDB=1osj |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/LEU3_THET8 LEU3_THET8] Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.[HAMAP-Rule:MF_01033]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/os/1osj_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1osj ConSurf].
<div style="clear:both"></div>


===STRUCTURE OF 3-ISOPROPYLMALATE DEHYDROGENASE===
==See Also==
 
*[[Isopropylmalate dehydrogenase|Isopropylmalate dehydrogenase]]
 
__TOC__
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_9051733}}, adds the Publication Abstract to the page
[[Category: Large Structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 9051733 is the PubMed ID number.
[[Category: Thermus thermophilus HB8]]
-->
[[Category: Akanuma S]]
{{ABSTRACT_PUBMED_9051733}}
[[Category: Moriyama H]]
 
[[Category: Oshima T]]
==About this Structure==
[[Category: Qu C]]
1OSJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OSJ OCA].
[[Category: Tanaka N]]
 
==Reference==
A mutation at the interface between domains causes rearrangement of domains in 3-isopropylmalate dehydrogenase., Qu C, Akanuma S, Moriyama H, Tanaka N, Oshima T, Protein Eng. 1997 Jan;10(1):45-52. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9051733 9051733]
[[Category: 3-isopropylmalate dehydrogenase]]
[[Category: Single protein]]
[[Category: Thermus thermophilus]]
[[Category: Akanuma, S.]]
[[Category: Moriyama, H.]]
[[Category: Oshima, T.]]
[[Category: Qu, C.]]
[[Category: Tanaka, N.]]
[[Category: Dehydrogenase]]
[[Category: Oxidoreductase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:25:58 2008''
Retrieved from "https://proteopedia.org/1osj"