2z35: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
 
(8 intermediate revisions by the same user not shown)
Line 1: Line 1:
{{Seed}}
[[Image:2z35.png|left|200px]]


<!--
==Crystal structure of immune receptor==
The line below this paragraph, containing "STRUCTURE_2z35", creates the "Structure Box" on the page.
<StructureSection load='2z35' size='340' side='right'caption='[[2z35]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2z35]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z35 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Z35 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2z35 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z35 OCA], [https://pdbe.org/2z35 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2z35 RCSB], [https://www.ebi.ac.uk/pdbsum/2z35 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2z35 ProSAT]</span></td></tr>
{{STRUCTURE_2z35|  PDB=2z35  |  SCENE=  }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q5R1F5_MOUSE Q5R1F5_MOUSE]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z3/2z35_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2z35 ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
All complexes of T cell receptors (TCRs) bound to peptide-major histocompatibility complex (pMHC) molecules assume a stereotyped binding 'polarity', despite wide variations in TCR-pMHC docking angles. However, existing TCR-pMHC crystal structures have failed to show broadly conserved pairwise interaction motifs. Here we determined the crystal structures of two TCRs encoded by the variable beta-chain 8.2 (V(beta)8.2), each bound to the MHC class II molecule I-A(u), and did energetic mapping of V(alpha) and V(beta) contacts with I-A(u). Together with two previously solved structures of V(beta)8.2-containing TCR-MHC complexes, we found four TCR-I-A complexes with structurally superimposable interactions between the V(beta) loops and the I-A alpha-helix. This examination of a narrow 'slice' of the TCR-MHC repertoire demonstrates what is probably one of many germline-derived TCR-MHC interaction 'codons'.


===Crystal structure of immune receptor===
Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon'.,Feng D, Bond CJ, Ely LK, Maynard J, Garcia KC Nat Immunol. 2007 Sep;8(9):975-83. Epub 2007 Aug 12. PMID:17694060<ref>PMID:17694060</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2z35" style="background-color:#fffaf0;"></div>


<!--
==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_17694060}}, adds the Publication Abstract to the page
*[[T-cell receptor 3D structures|T-cell receptor 3D structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 17694060 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_17694060}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Large Structures]]
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z35 OCA].
[[Category: Mus musculus]]
 
[[Category: Bond CJ]]
==Reference==
[[Category: Ely LK]]
Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon'., Feng D, Bond CJ, Ely LK, Maynard J, Garcia KC, Nat Immunol. 2007 Sep;8(9):975-83. Epub 2007 Aug 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17694060 17694060]
[[Category: Feng D]]
[[Category: Bond, C J.]]
[[Category: Garcia KC]]
[[Category: Ely, L K.]]
[[Category: Feng, D.]]
[[Category: Garcia, K C.]]
[[Category: Immune receptor]]
[[Category: Immune system]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:28:52 2008''
Retrieved from "https://proteopedia.org/2z35"