1k7a: Difference between revisions

From Proteopedia
Jump to navigationJump to search
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
New page: left|200px<br /><applet load="1k7a" size="450" color="white" frame="true" align="right" spinBox="true" caption="1k7a, resolution 2.80Å" /> '''Ets-1(331-440)+GGAG ...
 
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
 
(13 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:1k7a.gif|left|200px]]<br /><applet load="1k7a" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1k7a, resolution 2.80&Aring;" />
'''Ets-1(331-440)+GGAG duplex'''<br />


==Overview==
==Ets-1(331-440)+GGAG duplex==
Pax5 regulates the B cell-specific expression of the mb-1 gene together, with members of the Ets family of transcriptional activators. The Ets, proteins on their own bind poorly to the Pax5/Ets binding site, but can be, recruited to the site by cooperative interactions with Pax5. The structure, of the ETS domain of Ets-1 and the paired domain of Pax5 bound to DNA, reveals the molecular details of the selective recruitment of different, Ets proteins by Pax5. Comparison with structures of Ets-1 alone bound to, both high- and low-affinity DNA sites reveals that Pax5 alters the Ets-1, contacts with DNA. The ability of one protein to alter the DNA, sequence-specific contacts of another provides a general mechanism for, combinatorial regulation of transcription.
<StructureSection load='1k7a' size='340' side='right'caption='[[1k7a]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1k7a]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K7A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K7A FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k7a OCA], [https://pdbe.org/1k7a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k7a RCSB], [https://www.ebi.ac.uk/pdbsum/1k7a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k7a ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ETS1_MOUSE ETS1_MOUSE] Transcription factor.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k7/1k7a_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k7a ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
1K7A is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1K7A OCA].
*[[Ets1|Ets1]]
 
__TOC__
==Reference==
</StructureSection>
Structural studies of Ets-1/Pax5 complex formation on DNA., Garvie CW, Hagman J, Wolberger C, Mol Cell. 2001 Dec;8(6):1267-76. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11779502 11779502]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Single protein]]
[[Category: Garvie CW]]
[[Category: Garvie, C.W.]]
[[Category: Hagman J]]
[[Category: Hagman, J.]]
[[Category: Wolberger C]]
[[Category: Wolberger, C.]]
[[Category: ets domain]]
[[Category: transcription factor]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 18:54:48 2007''

Latest revision as of 07:44, 7 February 2024

Ets-1(331-440)+GGAG duplex

1k7a, resolution 2.80Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=1k7a&oldid=4045709"