1tsv: Difference between revisions

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{{Seed}}
[[Image:1tsv.png|left|200px]]


<!--
==THYMIDYLATE SYNTHASE R179A MUTANT==
The line below this paragraph, containing "STRUCTURE_1tsv", creates the "Structure Box" on the page.
<StructureSection load='1tsv' size='340' side='right'caption='[[1tsv]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1tsv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lacticaseibacillus_casei Lacticaseibacillus casei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TSV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TSV FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
{{STRUCTURE_1tsv| PDB=1tsv |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tsv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tsv OCA], [https://pdbe.org/1tsv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tsv RCSB], [https://www.ebi.ac.uk/pdbsum/1tsv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tsv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TYSY_LACCA TYSY_LACCA] Provides the sole de novo source of dTMP for DNA biosynthesis.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ts/1tsv_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tsv ConSurf].
<div style="clear:both"></div>


===THYMIDYLATE SYNTHASE R179A MUTANT===
==See Also==
 
*[[Thymidylate synthase|Thymidylate synthase]]
 
*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]
<!--
__TOC__
The line below this paragraph, {{ABSTRACT_PUBMED_9053905}}, adds the Publication Abstract to the page
</StructureSection>
(as it appears on PubMed at http://www.pubmed.gov), where 9053905 is the PubMed ID number.
[[Category: Lacticaseibacillus casei]]
-->
[[Category: Large Structures]]
{{ABSTRACT_PUBMED_9053905}}
[[Category: Finer-Moore J]]
 
[[Category: Stroud RM]]
==About this Structure==
1TSV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Lactobacillus_casei Lactobacillus casei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TSV OCA].
 
==Reference==
Contribution of a salt bridge to binding affinity and dUMP orientation to catalytic rate: mutation of a substrate-binding arginine in thymidylate synthase., Finer-Moore JS, Fauman EB, Morse RJ, Santi DV, Stroud RM, Protein Eng. 1996 Jan;9(1):69-75. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9053905 9053905]
[[Category: Lactobacillus casei]]
[[Category: Single protein]]
[[Category: Thymidylate synthase]]
[[Category: Finer-Moore, J.]]
[[Category: Stroud, R M.]]
[[Category: Methyltransferase]]
[[Category: Nucleotide biosynthesis]]
[[Category: Transferase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:26:28 2008''
Retrieved from "https://proteopedia.org/1tsv"