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New page: left|200px<br /> <applet load="2uvq" size="450" color="white" frame="true" align="right" spinBox="true" caption="2uvq, resolution 3.00Å" /> '''CRYSTAL STRUCTURE O...
 
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[[Image:2uvq.gif|left|200px]]<br />
<applet load="2uvq" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2uvq, resolution 3.00&Aring;" />
'''CRYSTAL STRUCTURE OF HUMAN URIDINE-CYTIDINE KINASE 1 IN COMPLEX WITH ADP'''<br />


==About this Structure==
==Crystal structure of human uridine-cytidine kinase 1 in complex with ADP==
2UVQ is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with ADP as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.48 2.7.1.48]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2UVQ OCA]].  
<StructureSection load='2uvq' size='340' side='right'caption='[[2uvq]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2uvq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UVQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2UVQ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2uvq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uvq OCA], [https://pdbe.org/2uvq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2uvq RCSB], [https://www.ebi.ac.uk/pdbsum/2uvq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2uvq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/UCK1_HUMAN UCK1_HUMAN] Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate (PubMed:11306702). Does not phosphorylate deoxyribonucleosides or purine ribonucleosides (PubMed:11306702). Can use ATP or GTP as a phosphate donor (PubMed:11306702). Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine (PubMed:11306702).<ref>PMID:11306702</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uv/2uvq_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2uvq ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C.]]
[[Category: Arrowsmith C]]
[[Category: Berg, S.Van.Den.]]
[[Category: Berglund H]]
[[Category: Berglund, H.]]
[[Category: Busam R]]
[[Category: Busam, R.]]
[[Category: Collins R]]
[[Category: Collins, R.]]
[[Category: Edwards A]]
[[Category: Edwards, A.]]
[[Category: Ericsson UB]]
[[Category: Ericsson, U.B.]]
[[Category: Flodin S]]
[[Category: Flodin, S.]]
[[Category: Flores A]]
[[Category: Flores, A.]]
[[Category: Graslund S]]
[[Category: Graslund, S.]]
[[Category: Hallberg BM]]
[[Category: Hallberg, B.M.]]
[[Category: Hammarstrom M]]
[[Category: Hammarstrom, M.]]
[[Category: Hogbom M]]
[[Category: Hogbom, M.]]
[[Category: Holmberg Schiavone L]]
[[Category: Johansson, I.]]
[[Category: Johansson I]]
[[Category: Karlberg, T.]]
[[Category: Karlberg T]]
[[Category: Kosinska, U.]]
[[Category: Kosinska U]]
[[Category: Kotenyova, T.]]
[[Category: Kotenyova T]]
[[Category: Moche, M.]]
[[Category: Moche M]]
[[Category: Nilsson, M.E.P.]]
[[Category: Nilsson MEP]]
[[Category: Nordlund, P.]]
[[Category: Nordlund P]]
[[Category: Nyman, T.]]
[[Category: Nyman T]]
[[Category: Ogg, D.]]
[[Category: Ogg D]]
[[Category: Persson, C.]]
[[Category: Persson C]]
[[Category: Sagemark, J.]]
[[Category: Sagemark J]]
[[Category: Schiavone, L.Holmberg.]]
[[Category: Stenmark P]]
[[Category: Stenmark, P.]]
[[Category: Sundstrom M]]
[[Category: Sundstrom, M.]]
[[Category: Thorsell AG]]
[[Category: Thorsell, A.G.]]
[[Category: Uppenberg J]]
[[Category: Uppenberg, J.]]
[[Category: Uppsten M]]
[[Category: Uppsten, M.]]
[[Category: Van Den Berg S]]
[[Category: Weigelt, J.]]
[[Category: Weigelt J]]
[[Category: Welin, M.]]
[[Category: Welin M]]
[[Category: ADP]]
[[Category: atp-binding]]
[[Category: kinase]]
[[Category: nucleoside kinase]]
[[Category: nucleotide-binding]]
[[Category: transferase]]
[[Category: uck]]
 
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Retrieved from "https://proteopedia.org/2uvq"