1nbi: Difference between revisions

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{{Seed}}
[[Image:1nbi.png|left|200px]]


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==Structure of R175K mutated glycine N-methyltransferase complexed with S-adenosylmethionine, R175K:SAM.==
The line below this paragraph, containing "STRUCTURE_1nbi", creates the "Structure Box" on the page.
<StructureSection load='1nbi' size='340' side='right'caption='[[1nbi]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1nbi]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NBI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NBI FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
{{STRUCTURE_1nbi|  PDB=1nbi  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nbi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nbi OCA], [https://pdbe.org/1nbi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nbi RCSB], [https://www.ebi.ac.uk/pdbsum/1nbi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nbi ProSAT]</span></td></tr>
 
</table>
===Structure of R175K mutated glycine N-methyltransferase complexed with S-adenosylmethionine, R175K:SAM.===
== Function ==
 
[https://www.uniprot.org/uniprot/GNMT_RAT GNMT_RAT] Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine.
 
== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nb/1nbi_consurf.spt"</scriptWhenChecked>
{{ABSTRACT_PUBMED_12859184}}
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 
    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
1NBI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NBI OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nbi ConSurf].
 
<div style="clear:both"></div>
==Reference==
__TOC__
Catalytic mechanism of glycine N-methyltransferase., Takata Y, Huang Y, Komoto J, Yamada T, Konishi K, Ogawa H, Gomi T, Fujioka M, Takusagawa F, Biochemistry. 2003 Jul 22;42(28):8394-402. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12859184 12859184]
</StructureSection>
[[Category: Glycine N-methyltransferase]]
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Single protein]]
[[Category: Takata Y]]
[[Category: Takata, Y.]]
[[Category: Takusagawa F]]
[[Category: Takusagawa, F.]]
[[Category: Catalytic mechanism]]
[[Category: Dynamical catalysis]]
[[Category: Glycine n-methyltransferase]]
[[Category: Methyltransferase]]
 
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