2akz: Difference between revisions

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{{Seed}}
[[Image:2akz.png|left|200px]]


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==Fluoride Inhibition of Enolase: Crystal Structure of the Inhibitory Complex==
The line below this paragraph, containing "STRUCTURE_2akz", creates the "Structure Box" on the page.
<StructureSection load='2akz' size='340' side='right'caption='[[2akz]], [[Resolution|resolution]] 1.36&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2akz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AKZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AKZ FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.36&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F:FLUORIDE+ION'>F</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
{{STRUCTURE_2akz| PDB=2akz |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2akz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2akz OCA], [https://pdbe.org/2akz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2akz RCSB], [https://www.ebi.ac.uk/pdbsum/2akz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2akz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ENOG_HUMAN ENOG_HUMAN] Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ak/2akz_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2akz ConSurf].
<div style="clear:both"></div>


===Fluoride Inhibition of Enolase: Crystal Structure of the Inhibitory Complex===
==See Also==
 
*[[Enolase 3D structures|Enolase 3D structures]]
 
__TOC__
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_16411755}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 16411755 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_16411755}}
 
==About this Structure==
2AKZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AKZ OCA].
 
==Reference==
Fluoride inhibition of enolase: crystal structure and thermodynamics., Qin J, Chai G, Brewer JM, Lovelace LL, Lebioda L, Biochemistry. 2006 Jan 24;45(3):793-800. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16411755 16411755]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Phosphopyruvate hydratase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Brewer JM]]
[[Category: Brewer, J M.]]
[[Category: Chai G]]
[[Category: Chai, G.]]
[[Category: Lovelace LL]]
[[Category: Lovelace, L L.]]
[[Category: Qin J]]
[[Category: Qin, J.]]
[[Category: Crystal structure]]
[[Category: Enolase]]
[[Category: Fluoride inhibition]]
[[Category: Glycolysis]]
[[Category: Isothermal titration calorimetry]]
[[Category: Negative cooperativity]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:28:40 2008''

Latest revision as of 09:13, 14 February 2024

Fluoride Inhibition of Enolase: Crystal Structure of the Inhibitory Complex

2akz, resolution 1.36Å

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