1y02: Difference between revisions

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{{Seed}}
[[Image:1y02.png|left|200px]]


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==Crystal Structure of a FYVE-type domain from caspase regulator CARP2==
The line below this paragraph, containing "STRUCTURE_1y02", creates the "Structure Box" on the page.
<StructureSection load='1y02' size='340' side='right'caption='[[1y02]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1y02]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y02 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y02 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_1y02|  PDB=1y02  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y02 OCA], [https://pdbe.org/1y02 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y02 RCSB], [https://www.ebi.ac.uk/pdbsum/1y02 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y02 ProSAT]</span></td></tr>
 
</table>
===Crystal Structure of a FYVE-type domain from caspase regulator CARP2===
== Function ==
 
[https://www.uniprot.org/uniprot/RFFL_HUMAN RFFL_HUMAN] Has E3 ubiquitin protein ligase activity. Regulates the levels of CASP8 and CASP10 by targeting them for proteasomal degradation. Has anti-apoptotic activity. May bind phosphatidylinositol phosphates.<ref>PMID:15069192</ref>
 
== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
The line below this paragraph, {{ABSTRACT_PUBMED_15576038}}, adds the Publication Abstract to the page
Check<jmol>
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y0/1y02_consurf.spt"</scriptWhenChecked>
{{ABSTRACT_PUBMED_15576038}}
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    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
1Y02 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y02 OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1y02 ConSurf].
 
<div style="clear:both"></div>
==Reference==
== References ==
Crystal structure of a FYVE-type zinc finger domain from the caspase regulator CARP2., Tibbetts MD, Shiozaki EN, Gu L, McDonald ER 3rd, El-Deiry WS, Shi Y, Structure. 2004 Dec;12(12):2257-63. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15576038 15576038]
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Gu, L.]]
[[Category: Gu L]]
[[Category: Shi, Y.]]
[[Category: Shi Y]]
[[Category: Shiozaki, E N.]]
[[Category: Shiozaki EN]]
[[Category: Tibbetts, M D.]]
[[Category: Tibbetts MD]]
[[Category: Carp2]]
[[Category: Caspase regulation]]
[[Category: Fyve]]
[[Category: Phosphoinositide binding]]
[[Category: Zinc-binding module]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:32:56 2008''

Latest revision as of 08:54, 14 February 2024

Crystal Structure of a FYVE-type domain from caspase regulator CARP2

1y02, resolution 1.80Å

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