1zc4: Difference between revisions

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{{Seed}}
[[Image:1zc4.png|left|200px]]


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==Crystal structure of the Ral-binding domain of Exo84 in complex with the active RalA==
The line below this paragraph, containing "STRUCTURE_1zc4", creates the "Structure Box" on the page.
<StructureSection load='1zc4' size='340' side='right'caption='[[1zc4]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1zc4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZC4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZC4 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
{{STRUCTURE_1zc4|  PDB=1zc4  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zc4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zc4 OCA], [https://pdbe.org/1zc4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zc4 RCSB], [https://www.ebi.ac.uk/pdbsum/1zc4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zc4 ProSAT]</span></td></tr>
 
</table>
===Crystal structure of the Ral-binding domain of Exo84 in complex with the active RalA===
== Function ==
 
[https://www.uniprot.org/uniprot/RALA_HUMAN RALA_HUMAN] Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Plays a role in the early stages of cytokinesis and is required to tether the exocyst to the cytokinetic furrow. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling. Key regulator of LPAR1 signaling and competes with ADRBK1 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells.<ref>PMID:18756269</ref> <ref>PMID:19306925</ref> <ref>PMID:20005108</ref>
 
== Evolutionary Conservation ==
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zc/1zc4_consurf.spt"</scriptWhenChecked>
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    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
1ZC4 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZC4 OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zc4 ConSurf].
 
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==Reference==
== References ==
Exo84 and Sec5 are competitive regulatory Sec6/8 effectors to the RalA GTPase., Jin R, Junutula JR, Matern HT, Ervin KE, Scheller RH, Brunger AT, EMBO J. 2005 Jun 15;24(12):2064-74. Epub 2005 May 26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15920473 15920473]
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Brunger, A T.]]
[[Category: Brunger AT]]
[[Category: Ervin, K E.]]
[[Category: Ervin KE]]
[[Category: Jin, R.]]
[[Category: Jin R]]
[[Category: Junutula, J R.]]
[[Category: Junutula JR]]
[[Category: Matern, H T.]]
[[Category: Matern HT]]
[[Category: Scheller, R H.]]
[[Category: Scheller RH]]
[[Category: Exocytosis]]
[[Category: Gtp-binding protein]]
[[Category: Small gtpase]]
 
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Retrieved from "https://proteopedia.org/1zc4"