2r14: Difference between revisions

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{{Seed}}
[[Image:2r14.png|left|200px]]


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==Structure of morphinone reductase in complex with tetrahydroNAD==
The line below this paragraph, containing "STRUCTURE_2r14", creates the "Structure Box" on the page.
<StructureSection load='2r14' size='340' side='right'caption='[[2r14]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2r14]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_putida Pseudomonas putida]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R14 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R14 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=TXD:1,4,5,6-TETRAHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>TXD</scene></td></tr>
{{STRUCTURE_2r14|  PDB=2r14  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r14 OCA], [https://pdbe.org/2r14 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r14 RCSB], [https://www.ebi.ac.uk/pdbsum/2r14 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r14 ProSAT]</span></td></tr>
 
</table>
===Structure of morphinone reductase in complex with tetrahydroNAD===
== Function ==
 
[https://www.uniprot.org/uniprot/Q51990_PSEPU Q51990_PSEPU]
 
== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
The line below this paragraph, {{ABSTRACT_PUBMED_17939663}}, adds the Publication Abstract to the page
Check<jmol>
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r1/2r14_consurf.spt"</scriptWhenChecked>
{{ABSTRACT_PUBMED_17939663}}
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    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
2R14 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_putida Pseudomonas putida]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R14 OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r14 ConSurf].
 
<div style="clear:both"></div>
==Reference==
__TOC__
Mutagenesis of morphinone reductase induces multiple reactive configurations and identifies potential ambiguity in kinetic analysis of enzyme tunneling mechanisms., Pudney CR, Hay S, Pang J, Costello C, Leys D, Sutcliffe MJ, Scrutton NS, J Am Chem Soc. 2007 Nov 14;129(45):13949-56. Epub 2007 Oct 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17939663 17939663]
</StructureSection>
[[Category: Large Structures]]
[[Category: Pseudomonas putida]]
[[Category: Pseudomonas putida]]
[[Category: Single protein]]
[[Category: Costello CL]]
[[Category: Costello, C L.]]
[[Category: Leys D]]
[[Category: Leys, D.]]
[[Category: Scrutton NS]]
[[Category: Scrutton, N S.]]
[[Category: Flavoprotein]]
[[Category: H-tunnelling]]
[[Category: Hydride transfer]]
[[Category: Morphinone reductase]]
[[Category: Nadh]]
[[Category: Oxidoreductase]]
 
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Retrieved from "https://proteopedia.org/2r14"