4bp2: Difference between revisions

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New page: left|200px<br /><applet load="4bp2" size="450" color="white" frame="true" align="right" spinBox="true" caption="4bp2, resolution 1.6Å" /> '''CRYSTALLOGRAPHIC REFI...
 
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[[Image:4bp2.gif|left|200px]]<br /><applet load="4bp2" size="450" color="white" frame="true" align="right" spinBox="true"
caption="4bp2, resolution 1.6&Aring;" />
'''CRYSTALLOGRAPHIC REFINEMENT OF BOVINE PRO-PHOSPHOLIPASE A2 AT 1.6 ANGSTROMS RESOLUTION'''<br />


==Overview==
==CRYSTALLOGRAPHIC REFINEMENT OF BOVINE PRO-PHOSPHOLIPASE A2 AT 1.6 ANGSTROMS RESOLUTION==
Bovine pro-phospholipase A2 (Mr = 14,520), trigonal, P3(1)21, a = b =, 46.5, c = 102.0 A, one molecule per asymmetric unit, lambda (Cu K alpha) =, 1.54 A. The model incorporating 895 protein atoms, two molecules of, 2-methyl-2,4-pentanediol, and 60 solvent water molecules, was refined by, restrained least squares to a residual R = 0.194 for 14,667 reflections, from 5 to 1.6 A resolution.
<StructureSection load='4bp2' size='340' side='right'caption='[[4bp2]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4bp2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BP2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BP2 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bp2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bp2 OCA], [https://pdbe.org/4bp2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bp2 RCSB], [https://www.ebi.ac.uk/pdbsum/4bp2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bp2 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PA21B_BOVIN PA21B_BOVIN] PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bp/4bp2_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=4bp2 ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Bovine pro-phospholipase A2 (Mr = 14,520), trigonal, P3(1)21, a = b = 46.5, c = 102.0 A, one molecule per asymmetric unit, lambda (Cu K alpha) = 1.54 A. The model incorporating 895 protein atoms, two molecules of 2-methyl-2,4-pentanediol, and 60 solvent water molecules, was refined by restrained least squares to a residual R = 0.194 for 14,667 reflections from 5 to 1.6 A resolution.


==About this Structure==
Crystallographic refinement of bovine pro-phospholipase A2 at 1.6 A resolution.,Finzel BC, Weber PC, Ohlendorf DH, Salemme FR Acta Crystallogr B. 1991 Oct 1;47 ( Pt 5):814-6. PMID:1793547<ref>PMID:1793547</ref>
4BP2 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with CA and MPD as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=4BP2 OCA].


==Reference==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
Crystallographic refinement of bovine pro-phospholipase A2 at 1.6 A resolution., Finzel BC, Weber PC, Ohlendorf DH, Salemme FR, Acta Crystallogr B. 1991 Oct 1;47 ( Pt 5):814-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=1793547 1793547]
</div>
<div class="pdbe-citations 4bp2" style="background-color:#fffaf0;"></div>
 
==See Also==
*[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Phospholipase A(2)]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Finzel BC]]
[[Category: Finzel, B.C.]]
[[Category: Ohlendorf DH]]
[[Category: Ohlendorf, D.H.]]
[[Category: Salemme FR]]
[[Category: Salemme, F.R.]]
[[Category: Weber PC]]
[[Category: Weber, P.C.]]
[[Category: CA]]
[[Category: MPD]]
[[Category: carboxylic ester hydrolase zymogen]]
 
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Latest revision as of 08:21, 23 October 2024

CRYSTALLOGRAPHIC REFINEMENT OF BOVINE PRO-PHOSPHOLIPASE A2 AT 1.6 ANGSTROMS RESOLUTION

4bp2, resolution 1.60Å

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