1y2u: Difference between revisions

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{{Seed}}
[[Image:1y2u.png|left|200px]]


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==Crystal structure of the common edible mushroom (Agaricus bisporus) lectin in complex with Lacto-N-biose==
The line below this paragraph, containing "STRUCTURE_1y2u", creates the "Structure Box" on the page.
<StructureSection load='1y2u' size='340' side='right'caption='[[1y2u]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1y2u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Agaricus_bisporus Agaricus bisporus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y2U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y2U FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
{{STRUCTURE_1y2u|  PDB=1y2u  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y2u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y2u OCA], [https://pdbe.org/1y2u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y2u RCSB], [https://www.ebi.ac.uk/pdbsum/1y2u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y2u ProSAT]</span></td></tr>
 
</table>
===Crystal structure of the common edible mushroom (Agaricus bisporus) lectin in complex with Lacto-N-biose===
== Function ==
 
[https://www.uniprot.org/uniprot/ABL_AGABI ABL_AGABI] Lectin that recognizes O-linked galactose-beta-1,3-N-acetylgalactosamine, a disaccharide (Thomsen-Friedenreich antigen or T-disaccharide), present on cell surface glycoproteins. Can also bind galactose-beta-1,3-N-acetylglucosamine. Does not bind monosaccharides. Can be internalized by clathrin-coated vesicles after binding to surface glycoproteins. After internalization it inhibits nuclear import of nuclear localization signal dependent proteins. Inhibits proliferation of malignant cells without cytotoxicity for normal cells.<ref>PMID:4343164</ref> <ref>PMID:8402638</ref> <ref>PMID:9988731</ref>
 
== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
The line below this paragraph, {{ABSTRACT_PUBMED_15596442}}, adds the Publication Abstract to the page
Check<jmol>
(as it appears on PubMed at http://www.pubmed.gov), where 15596442 is the PubMed ID number.
  <jmolCheckbox>
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y2/1y2u_consurf.spt"</scriptWhenChecked>
{{ABSTRACT_PUBMED_15596442}}
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 
    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
1Y2U is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Agaricus_bisporus Agaricus bisporus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y2U OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1y2u ConSurf].
 
<div style="clear:both"></div>
==Reference==
== References ==
The antineoplastic lectin of the common edible mushroom (Agaricus bisporus) has two binding sites, each specific for a different configuration at a single epimeric hydroxyl., Carrizo ME, Capaldi S, Perduca M, Irazoqui FJ, Nores GA, Monaco HL, J Biol Chem. 2005 Mar 18;280(11):10614-23. Epub 2004 Dec 13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15596442 15596442]
<references/>
 
__TOC__
Crystallization and preliminary X-ray study of the common edible mushroom (Agaricus bisporus) lectin., Carrizo ME, Irazoqui FJ, Lardone RD, Nores GA, Curtino JA, Capaldi S, Perduca M, Monaco HL, Acta Crystallogr D Biol Crystallogr. 2004 Apr;60(Pt 4):718-20. Epub 2004, Mar 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15039564 15039564]
</StructureSection>
[[Category: Agaricus bisporus]]
[[Category: Single protein]]
[[Category: Capaldi, S.]]
[[Category: Carrizo, M E.]]
[[Category: Irazoqui, F J.]]
[[Category: Monaco, H L.]]
[[Category: Nores, G A.]]
[[Category: Perduca, M.]]
[[Category: Abl]]
[[Category: Agaricus bisporus]]
[[Category: Agaricus bisporus]]
[[Category: Lacto-n-biose]]
[[Category: Large Structures]]
[[Category: Lectin]]
[[Category: Capaldi S]]
[[Category: Mushroom]]
[[Category: Carrizo ME]]
 
[[Category: Irazoqui FJ]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:50:38 2008''
[[Category: Monaco HL]]
[[Category: Nores GA]]
[[Category: Perduca M]]

Latest revision as of 13:37, 13 March 2024

Crystal structure of the common edible mushroom (Agaricus bisporus) lectin in complex with Lacto-N-biose

1y2u, resolution 1.85Å

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