1wnd: Difference between revisions

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{{Seed}}
[[Image:1wnd.png|left|200px]]


<!--
==Escherichia coli YdcW gene product is a medium-chain aldehyde dehydrogenase as determined by kinetics and crystal structure==
The line below this paragraph, containing "STRUCTURE_1wnd", creates the "Structure Box" on the page.
<StructureSection load='1wnd' size='340' side='right'caption='[[1wnd]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1wnd]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WND OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WND FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
{{STRUCTURE_1wnd|  PDB=1wnd  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wnd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wnd OCA], [https://pdbe.org/1wnd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wnd RCSB], [https://www.ebi.ac.uk/pdbsum/1wnd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wnd ProSAT]</span></td></tr>
 
</table>
===Escherichia coli YdcW gene product is a medium-chain aldehyde dehydrogenase as determined by kinetics and crystal stucture===
== Function ==
 
[https://www.uniprot.org/uniprot/ABDH_ECOLI ABDH_ECOLI] Catalyzes the oxidation of 1-pyrroline, which is spontaneously formed from 4-aminobutanal, leading to 4-aminobutanoate (GABA). Can also oxidize n-alkyl medium-chain aldehydes, but with a lower catalytic efficiency.<ref>PMID:16023116</ref> <ref>PMID:15381418</ref>
 
== Evolutionary Conservation ==
<!--
[[Image:Consurf_key_small.gif|200px|right]]
The line below this paragraph, {{ABSTRACT_PUBMED_15381418}}, adds the Publication Abstract to the page
Check<jmol>
(as it appears on PubMed at http://www.pubmed.gov), where 15381418 is the PubMed ID number.
  <jmolCheckbox>
-->
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wn/1wnd_consurf.spt"</scriptWhenChecked>
{{ABSTRACT_PUBMED_15381418}}
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 
    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
1WND is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WND OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wnd ConSurf].
 
<div style="clear:both"></div>
==Reference==
== References ==
Crystal structure and kinetics identify Escherichia coli YdcW gene product as a medium-chain aldehyde dehydrogenase., Gruez A, Roig-Zamboni V, Grisel S, Salomoni A, Valencia C, Campanacci V, Tegoni M, Cambillau C, J Mol Biol. 2004 Oct 8;343(1):29-41. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15381418 15381418]
<references/>
[[Category: Betaine-aldehyde dehydrogenase]]
__TOC__
[[Category: Escherichia coli]]
</StructureSection>
[[Category: Single protein]]
[[Category: Escherichia coli K-12]]
[[Category: Cambillau, C.]]
[[Category: Large Structures]]
[[Category: Gruez, A.]]
[[Category: Cambillau C]]
[[Category: Roig-Zamboni, V.]]
[[Category: Gruez A]]
[[Category: Tegoni, M.]]
[[Category: Roig-Zamboni V]]
[[Category: Aldehyde dehydrogenase]]
[[Category: Tegoni M]]
[[Category: Crystal structure]]
[[Category: Fluorescence]]
[[Category: Kinetic]]
[[Category: Nadh]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:59:41 2008''

Latest revision as of 13:32, 13 March 2024

Escherichia coli YdcW gene product is a medium-chain aldehyde dehydrogenase as determined by kinetics and crystal structure

1wnd, resolution 2.10Å

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