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New page: left|200px<br /><applet load="4est" size="450" color="white" frame="true" align="right" spinBox="true" caption="4est, resolution 1.78Å" /> '''CRYSTAL STRUCTURE OF...
 
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[[Image:4est.gif|left|200px]]<br /><applet load="4est" size="450" color="white" frame="true" align="right" spinBox="true"
caption="4est, resolution 1.78&Aring;" />
'''CRYSTAL STRUCTURE OF THE COVALENT COMPLEX FORMED BY A PEPTIDYL ALPHA,ALPHA-DIFLUORO-BETA-KETO AMIDE WITH PORCINE PANCREATIC ELASTASE AT 1.78-ANGSTROMS RESOLUTION'''<br />


==About this Structure==
==CRYSTAL STRUCTURE OF THE COVALENT COMPLEX FORMED BY A PEPTIDYL ALPHA,ALPHA-DIFLUORO-BETA-KETO AMIDE WITH PORCINE PANCREATIC ELASTASE AT 1.78-ANGSTROMS RESOLUTION==
4EST is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ] with SO4, CA, ACE and FPA as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Pancreatic_elastase Pancreatic elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.36 3.4.21.36] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=4EST OCA].
<StructureSection load='4est' size='340' side='right'caption='[[4est]], [[Resolution|resolution]] 1.78&Aring;' scene=''>
[[Category: Pancreatic elastase]]
== Structural highlights ==
[[Category: Single protein]]
<table><tr><td colspan='2'>[[4est]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EST OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EST FirstGlance]. <br>
[[Category: Meyerjunior, E.F.]]
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.78&#8491;</td></tr>
[[Category: Radhakrishnan, R.]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FPA:BROMO(DIFLUORO)ACETIC+ACID'>FPA</scene>, <scene name='pdbligand=PEA:2-PHENYLETHYLAMINE'>PEA</scene>, <scene name='pdbligand=PRD_000236:N-acetyl-L-alanyl-N-{(1S)-3,3-difluoro-1-(1-methylethyl)-2,4-dioxo-4-[(2-phenylethyl)amino]butyl}-L-prolinamide'>PRD_000236</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=VAI:(2S)-2-AMINO-3-METHYLBUTANE-1,1-DIOL'>VAI</scene></td></tr>
[[Category: Rosenfieldjunior, R.E.]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4est FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4est OCA], [https://pdbe.org/4est PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4est RCSB], [https://www.ebi.ac.uk/pdbsum/4est PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4est ProSAT]</span></td></tr>
[[Category: Takahashi, L.H.]]
</table>
[[Category: Trainor, D.A.]]
== Function ==
[[Category: ACE]]
[https://www.uniprot.org/uniprot/CELA1_PIG CELA1_PIG] Acts upon elastin.
[[Category: CA]]
== Evolutionary Conservation ==
[[Category: FPA]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: SO4]]
Check<jmol>
[[Category: hydrolase(serine proteinase)]]
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/es/4est_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=4est ConSurf].
<div style="clear:both"></div>


''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 19:34:30 2007''
==See Also==
*[[Elastase 3D structures|Elastase 3D structures]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Sus scrofa]]
[[Category: Meyerjunior EF]]
[[Category: Radhakrishnan R]]
[[Category: Rosenfieldjunior RE]]
[[Category: Takahashi LH]]
[[Category: Trainor DA]]

Latest revision as of 08:19, 9 October 2024

CRYSTAL STRUCTURE OF THE COVALENT COMPLEX FORMED BY A PEPTIDYL ALPHA,ALPHA-DIFLUORO-BETA-KETO AMIDE WITH PORCINE PANCREATIC ELASTASE AT 1.78-ANGSTROMS RESOLUTION

4est, resolution 1.78Å

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