2ecu: Difference between revisions
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==Crystal structure of flavin reductase component (HpaC) of 4-hydroxyphenylacetate 3-monooxygenase== | |||
<StructureSection load='2ecu' size='340' side='right'caption='[[2ecu]], [[Resolution|resolution]] 1.30Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2ecu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ECU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ECU FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=12P:DODECAETHYLENE+GLYCOL'>12P</scene>, <scene name='pdbligand=1PG:2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL'>1PG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ecu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ecu OCA], [https://pdbe.org/2ecu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ecu RCSB], [https://www.ebi.ac.uk/pdbsum/2ecu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ecu ProSAT], [https://www.topsan.org/Proteins/RSGI/2ecu TOPSAN]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/HPAC_THET8 HPAC_THET8] Catalyzes the reduction of free flavins (FMN, FAD and riboflavin) by NADH. Subsequently, the reduced flavins diffuse to the large HpaB component.<ref>PMID:17729270</ref> | |||
== Evolutionary Conservation == | |||
< | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ec/2ecu_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
== | </jmolCheckbox> | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ecu ConSurf]. | |||
<div style="clear:both"></div> | |||
== | == References == | ||
<references/> | |||
[ | __TOC__ | ||
[[ | </StructureSection> | ||
[ | [[Category: Large Structures]] | ||
[[ | [[Category: Thermus thermophilus HB8]] | ||
[ | [[Category: Ebihara A]] | ||
[[Category: | [[Category: Hisano T]] | ||
[[Category: | [[Category: Iwasaki W]] | ||
[[Category: | [[Category: Kim SH]] | ||
[[Category: | [[Category: Miki K]] | ||
[[Category: | |||
[[Category: | |||
[[Category: | |||
Latest revision as of 06:25, 3 April 2024
Crystal structure of flavin reductase component (HpaC) of 4-hydroxyphenylacetate 3-monooxygenase
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