2trs: Difference between revisions

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{{Seed}}
[[Image:2trs.png|left|200px]]


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==CRYSTAL STRUCTURES OF MUTANT (BETAK87T) TRYPTOPHAN SYNTHASE ALPHA2 BETA2 COMPLEX WITH LIGANDS BOUND TO THE ACTIVE SITES OF THE ALPHA AND BETA SUBUNITS REVEAL LIGAND-INDUCED CONFORMATIONAL CHANGES==
The line below this paragraph, containing "STRUCTURE_2trs", creates the "Structure Box" on the page.
<StructureSection load='2trs' size='340' side='right'caption='[[2trs]], [[Resolution|resolution]] 2.04&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2trs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2TRS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2TRS FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.04&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IPL:INDOLE-3-PROPANOL+PHOSPHATE'>IPL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PLS:[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL]-SERINE'>PLS</scene></td></tr>
{{STRUCTURE_2trs| PDB=2trs |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2trs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2trs OCA], [https://pdbe.org/2trs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2trs RCSB], [https://www.ebi.ac.uk/pdbsum/2trs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2trs ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TRPA_SALTY TRPA_SALTY] The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tr/2trs_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2trs ConSurf].
<div style="clear:both"></div>


===CRYSTAL STRUCTURES OF MUTANT (BETAK87T) TRYPTOPHAN SYNTHASE ALPHA2 BETA2 COMPLEX WITH LIGANDS BOUND TO THE ACTIVE SITES OF THE ALPHA AND BETA SUBUNITS REVEAL LIGAND-INDUCED CONFORMATIONAL CHANGES===
==See Also==
 
*[[Tryptophan synthase 3D structures|Tryptophan synthase 3D structures]]
 
__TOC__
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_9201907}}, adds the Publication Abstract to the page
[[Category: Large Structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 9201907 is the PubMed ID number.
[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
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[[Category: Ahmed SA]]
{{ABSTRACT_PUBMED_9201907}}
[[Category: Davies DR]]
 
[[Category: Hyde CC]]
==About this Structure==
[[Category: Miles EW]]
2TRS is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Salmonella_typhimurium Salmonella typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2TRS OCA].
[[Category: Parris KD]]
 
[[Category: Rhee S]]
==Reference==
Crystal structures of a mutant (betaK87T) tryptophan synthase alpha2beta2 complex with ligands bound to the active sites of the alpha- and beta-subunits reveal ligand-induced conformational changes., Rhee S, Parris KD, Hyde CC, Ahmed SA, Miles EW, Davies DR, Biochemistry. 1997 Jun 24;36(25):7664-80. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9201907 9201907]
[[Category: Protein complex]]
[[Category: Salmonella typhimurium]]
[[Category: Tryptophan synthase]]
[[Category: Ahmed, S A.]]
[[Category: Davies, D R.]]
[[Category: Hyde, C C.]]
[[Category: Miles, E W.]]
[[Category: Parris, K D.]]
[[Category: Rhee, S.]]
[[Category: Carbon-oxygen lyase]]
[[Category: Lyase]]
[[Category: Pyridoxal phosphate]]
[[Category: Tryptophan biosynthesis]]
 
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Retrieved from "https://proteopedia.org/2trs"