2frh: Difference between revisions

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{{Seed}}
[[Image:2frh.png|left|200px]]


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==Crystal Structure of Sara, A Transcription Regulator From Staphylococcus Aureus==
The line below this paragraph, containing "STRUCTURE_2frh", creates the "Structure Box" on the page.
<StructureSection load='2frh' size='340' side='right'caption='[[2frh]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2frh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FRH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FRH FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
{{STRUCTURE_2frh|  PDB=2frh  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2frh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2frh OCA], [https://pdbe.org/2frh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2frh RCSB], [https://www.ebi.ac.uk/pdbsum/2frh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2frh ProSAT]</span></td></tr>
 
</table>
===Crystal Structure of Sara, A Transcription Regulator From Staphylococcus Aureus===
== Function ==
 
[https://www.uniprot.org/uniprot/SARA_STAAW SARA_STAAW] Global regulator with both positive and negative effects that controls the expression of several virulence factors and the biofilm formation process in a cell density-dependent manner (By similarity). Required for transcription of primary transcripts RNAII and RNAIII generated by agr (virulence accessory gene regulator) locus. Negatively regulates the expression of spa (protein A) and aur (metalloprotease aureolysin).
 
== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fr/2frh_consurf.spt"</scriptWhenChecked>
{{ABSTRACT_PUBMED_16455801}}
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    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
2FRH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FRH OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2frh ConSurf].
 
<div style="clear:both"></div>
==Reference==
__TOC__
Structural and function analyses of the global regulatory protein SarA from Staphylococcus aureus., Liu Y, Manna AC, Pan CH, Kriksunov IA, Thiel DJ, Cheung AL, Zhang G, Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2392-7. Epub 2006 Feb 2. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16455801 16455801]
</StructureSection>
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
[[Category: Cheung, A L.]]
[[Category: Cheung AL]]
[[Category: Ingavale, S.]]
[[Category: Ingavale S]]
[[Category: Liu, Y.]]
[[Category: Liu Y]]
[[Category: Manna, A C.]]
[[Category: Manna AC]]
[[Category: Zhang, G.]]
[[Category: Zhang G]]
[[Category: Divalent metal binding]]
[[Category: Winged-helix protein]]
 
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Retrieved from "https://proteopedia.org/2frh"