1uxd: Difference between revisions

From Proteopedia
Jump to navigationJump to search
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
New page: left|200px<br /> <applet load="1uxd" size="450" color="white" frame="true" align="right" spinBox="true" caption="1uxd" /> '''FRUCTOSE REPRESSOR DNA-BINDING DOMAIN, NMR,...
 
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
 
(21 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:1uxd.gif|left|200px]]<br />
<applet load="1uxd" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1uxd" />
'''FRUCTOSE REPRESSOR DNA-BINDING DOMAIN, NMR, 34 STRUCTURES'''<br />


==Overview==
==Fructose repressor DNA-binding domain, NMR, 34 structures==
FruR is an Escherichia coli transcriptional regulator that belongs to the, LacI DNA-binding protein family. By using 1H and 15N NMR spectroscopy, we, have determined the three-dimensional solution structure of the FruR, N-terminal DNA-binding domain consisting of 57 amino acid residues. A, total of 809 NMR-derived distances and 54 dihedral angle constraints have, been used for molecular modelling with the X-PLOR program. The resulting, set of calculated structures presents an average root-mean-square, deviation of 0.37 A at the main-chain level for the first 47 residues., This highly defined N-terminal part of the structure reveals a similar, topology for the three alpha-helices when compared to the 3D structures of, LacI and PurR counterparts. The most striking difference lies in the, ... [[http://ispc.weizmann.ac.il/pmbin/getpm?9237914 (full description)]]
<StructureSection load='1uxd' size='340' side='right'caption='[[1uxd]]' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[1uxd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UXD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UXD FirstGlance]. <br>
1UXD is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UXD OCA]].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uxd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uxd OCA], [https://pdbe.org/1uxd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uxd RCSB], [https://www.ebi.ac.uk/pdbsum/1uxd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uxd ProSAT]</span></td></tr>
==Reference==
</table>
Three-dimensional structure of the DNA-binding domain of the fructose repressor from Escherichia coli by 1H and 15N NMR., Penin F, Geourjon C, Montserret R, Bockmann A, Lesage A, Yang YS, Bonod-Bidaud C, Cortay JC, Negre D, Cozzone AJ, Deleage G, J Mol Biol. 1997 Jul 18;270(3):496-510. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9237914 9237914]
== Function ==
[[Category: Escherichia coli]]
[https://www.uniprot.org/uniprot/CRA_ECOLI CRA_ECOLI] Global transcriptional regulator, which plays an important role in the regulation of carbon metabolism. Activates transcription of genes encoding biosynthetic and oxidative enzymes (involved in Krebs cycle, glyoxylate shunt and gluconeogenesis, such as ppsA and fbp). Represses genes involved in sugar catabolism, such as fruB, pfkA, pykF and adhE. Binds asymmetrically to the two half-sites of its operator.<ref>PMID:16115199</ref> <ref>PMID:8195118</ref> <ref>PMID:8230205</ref> <ref>PMID:8550429</ref> <ref>PMID:8577250</ref> <ref>PMID:8858581</ref> <ref>PMID:9084760</ref> <ref>PMID:9371462</ref>
[[Category: Single protein]]
== Evolutionary Conservation ==
[[Category: Bockmann, A.]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: Bonod-Bidaud, C.]]
Check<jmol>
[[Category: Cortay, J.C.]]
  <jmolCheckbox>
[[Category: Cozzone, A.J.]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ux/1uxd_consurf.spt"</scriptWhenChecked>
[[Category: Deleage, G.]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: Geourjon, C.]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: Lesage, A.]]
  </jmolCheckbox>
[[Category: Montserret, R.]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1uxd ConSurf].
[[Category: Negre, D.]]
<div style="clear:both"></div>
[[Category: Penin, F.]]
== References ==
[[Category: Yang, Y.]]
<references/>
[[Category: dna-binding protein]]
__TOC__
[[Category: fructose repressor]]
</StructureSection>
[[Category: laci family]]
[[Category: Escherichia coli K-12]]
[[Category: transcription regulation]]
[[Category: Large Structures]]
 
[[Category: Bockmann A]]
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 20:19:00 2007''
[[Category: Bonod-Bidaud C]]
[[Category: Cortay JC]]
[[Category: Cozzone AJ]]
[[Category: Deleage G]]
[[Category: Geourjon C]]
[[Category: Lesage A]]
[[Category: Montserret R]]
[[Category: Negre D]]
[[Category: Penin F]]
[[Category: Yang Y]]

Latest revision as of 06:35, 1 May 2024

Fructose repressor DNA-binding domain, NMR, 34 structures

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=1uxd&oldid=4135206"