2jq6: Difference between revisions

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{{Seed}}
[[Image:2jq6.png|left|200px]]


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==Structure of EH-domain of EHD1==
The line below this paragraph, containing "STRUCTURE_2jq6", creates the "Structure Box" on the page.
<StructureSection load='2jq6' size='340' side='right'caption='[[2jq6]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2jq6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JQ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JQ6 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
{{STRUCTURE_2jq6|  PDB=2jq6  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jq6 OCA], [https://pdbe.org/2jq6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jq6 RCSB], [https://www.ebi.ac.uk/pdbsum/2jq6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jq6 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/EHD1_HUMAN EHD1_HUMAN] Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes.<ref>PMID:15020713</ref> <ref>PMID:17233914</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jq/2jq6_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jq6 ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
EHD1 is a member of the mammalian C-terminal Eps15 homology domain (EH) containing protein family, and regulates the recycling of various receptors from the endocytic recycling compartment to the plasma membrane. The EH domain of EHD1 binds to proteins containing either an Asn-Pro-Phe or Asp-Pro-Phe motif, and plays an important role in the subcellular localization and function of EHD1. Thus far, the structures of five N-terminal EH domains from other proteins have been solved, but to date, the structure of the EH domains from the four C-terminal EHD family paralogs remains unknown. In this study, we have assigned the 133 C-terminal residues of EHD1, which includes the EH domain, and solved its solution structure. While the overall structure resembles that of the second of the three N-terminal Eps15 EH domains, potentially significant differences in surface charge and the structure of the tripeptide-binding pocket are discussed.


===Structure of EH-domain of EHD1===
EH domain of EHD1.,Kieken F, Jovic M, Naslavsky N, Caplan S, Sorgen PL J Biomol NMR. 2007 Dec;39(4):323-9. Epub 2007 Sep 26. PMID:17899392<ref>PMID:17899392</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
The line below this paragraph, {{ABSTRACT_PUBMED_17899392}}, adds the Publication Abstract to the page
<div class="pdbe-citations 2jq6" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 17899392 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_17899392}}
__TOC__
 
</StructureSection>
==About this Structure==
2JQ6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JQ6 OCA].
 
==Reference==
EH domain of EHD1., Kieken F, Jovic M, Naslavsky N, Caplan S, Sorgen PL, J Biomol NMR. 2007 Dec;39(4):323-9. Epub 2007 Sep 26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17899392 17899392]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Caplan, S.]]
[[Category: Caplan S]]
[[Category: Jovic, M.]]
[[Category: Jovic M]]
[[Category: Kieken, F P.]]
[[Category: Kieken FP]]
[[Category: Sorgen, P L.]]
[[Category: Sorgen PL]]
[[Category: Eh domain]]
[[Category: Ehd-1]]
[[Category: Metal binding protein]]
 
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Retrieved from "https://proteopedia.org/2jq6"