1nn0: Difference between revisions

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{{Seed}}
[[Image:1nn0.png|left|200px]]


<!--
==Crystal structure of human thymidylate kinase with ddTMP and ADP==
The line below this paragraph, containing "STRUCTURE_1nn0", creates the "Structure Box" on the page.
<StructureSection load='1nn0' size='340' side='right'caption='[[1nn0]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1nn0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NN0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NN0 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2DT:3-DEOXYTHYMIDINE-5-MONOPHOSPHATE'>2DT</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
{{STRUCTURE_1nn0|  PDB=1nn0 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nn0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nn0 OCA], [https://pdbe.org/1nn0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nn0 RCSB], [https://www.ebi.ac.uk/pdbsum/1nn0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nn0 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KTHY_HUMAN KTHY_HUMAN] Catalyzes the conversion of dTMP to dTDP.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nn/1nn0_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nn0 ConSurf].
<div style="clear:both"></div>


===Crystal structure of human thymidylate kinase with ddTMP and ADP===
==See Also==
 
*[[Thymidylate kinase 3D structures|Thymidylate kinase 3D structures]]
 
__TOC__
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_12614151}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 12614151 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_12614151}}
 
==About this Structure==
1NN0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NN0 OCA].
 
==Reference==
Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds., Ostermann N, Segura-Pena D, Meier C, Veit T, Monnerjahn C, Konrad M, Lavie A, Biochemistry. 2003 Mar 11;42(9):2568-77. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12614151 12614151]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: DTMP kinase]]
[[Category: Konrad M]]
[[Category: Konrad, M.]]
[[Category: Lavie A]]
[[Category: Lavie, A.]]
[[Category: Meier C]]
[[Category: Meier, C.]]
[[Category: Monnerjahn M]]
[[Category: Monnerjahn, M.]]
[[Category: Ostermann N]]
[[Category: Ostermann, N.]]
[[Category: Segura-Pena D]]
[[Category: Segura-Pena, D.]]
[[Category: Veit T]]
[[Category: Veit, T.]]
[[Category: Dideoxythymidine]]
[[Category: P-loop]]
[[Category: Thymidylate kinase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:45:00 2008''

Latest revision as of 07:57, 14 February 2024

Crystal structure of human thymidylate kinase with ddTMP and ADP

1nn0, resolution 1.60Å

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