2o3m: Difference between revisions

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{{Seed}}
[[Image:2o3m.png|left|200px]]


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==Monomeric G-DNA tetraplex from human C-kit promoter==
The line below this paragraph, containing "STRUCTURE_2o3m", creates the "Structure Box" on the page.
<StructureSection load='2o3m' size='340' side='right'caption='[[2o3m]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2o3m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O3M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O3M FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o3m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o3m OCA], [https://pdbe.org/2o3m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o3m RCSB], [https://www.ebi.ac.uk/pdbsum/2o3m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o3m ProSAT]</span></td></tr>
{{STRUCTURE_2o3m|  PDB=2o3m  |  SCENE=  }}
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The c-kit oncogene is an important target in the treatment of gastrointestinal tumors. A potential approach to inhibition of the expression of this gene involves selective stabilization of G-quadruplex structures that may be induced to form in the c-kit promoter region. Here we report on the structure of an unprecedented intramolecular G-quadruplex formed by a G-rich sequence in the c-kit promoter in K+ solution. The structure represents a new folding topology with several unique features. Most strikingly, an isolated guanine is involved in G-tetrad core formation, despite the presence of four three-guanine tracts. There are four loops: two single-residue double-chain-reversal loops, a two-residue loop, and a five-residue stem-loop, which contain base-pairing alignments. This unique structural scaffold provides a highly specific platform for the future design of ligands specifically targeted to the promoter DNA of c-kit.


===Monomeric G-DNA tetraplex from human C-kit promoter===
Structure of an unprecedented G-quadruplex scaffold in the human c-kit promoter.,Phan AT, Kuryavyi V, Burge S, Neidle S, Patel DJ J Am Chem Soc. 2007 Apr 11;129(14):4386-92. Epub 2007 Mar 16. PMID:17362008<ref>PMID:17362008</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The line below this paragraph, {{ABSTRACT_PUBMED_17362008}}, adds the Publication Abstract to the page
<div class="pdbe-citations 2o3m" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 17362008 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_17362008}}
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</StructureSection>
==About this Structure==
[[Category: Homo sapiens]]
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O3M OCA].
[[Category: Large Structures]]
 
[[Category: Burge S]]
==Reference==
[[Category: Kuryavyi VV]]
Structure of an unprecedented G-quadruplex scaffold in the human c-kit promoter., Phan AT, Kuryavyi V, Burge S, Neidle S, Patel DJ, J Am Chem Soc. 2007 Apr 11;129(14):4386-92. Epub 2007 Mar 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17362008 17362008]
[[Category: Neidle S]]
[[Category: Burge, S.]]
[[Category: Patel DJ]]
[[Category: Kuryavyi, V V.]]
[[Category: Phan AT]]
[[Category: Neidle, S.]]
[[Category: Patel, D J.]]
[[Category: Phan, A T.]]
[[Category: Edgewise]]
[[Category: G-tetrad;parallel g-quadruplex]]
[[Category: Single-residue cha reversal,5-nucleotide snap-back loops;broken strand topolog]]
 
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Retrieved from "https://proteopedia.org/2o3m"