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{{Seed}}
[[Image:2iew.png|left|200px]]


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==Crystal structure of Inositol Phosphate Multikinase Ipk2 from S. cerevisiae==
The line below this paragraph, containing "STRUCTURE_2iew", creates the "Structure Box" on the page.
<StructureSection load='2iew' size='340' side='right'caption='[[2iew]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2iew]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IEW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IEW FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
{{STRUCTURE_2iew|  PDB=2iew  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iew OCA], [https://pdbe.org/2iew PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iew RCSB], [https://www.ebi.ac.uk/pdbsum/2iew PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iew ProSAT]</span></td></tr>
 
</table>
===Crystal structure of Inositol Phosphate Multikinase Ipk2 from S. cerevisiae===
== Function ==
 
[https://www.uniprot.org/uniprot/IPMK_YEAST IPMK_YEAST] Has kinase activity and phosphorylates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol 1,3,4,5-tetrakisphosphate (Ins(1,3,4,5)P4). Has low kinase activity towards InsP6. With ARG80, ARG81 and MCM1, coordinates the expression of arginine anabolic and catabolic genes in response to arginine. Recruites ARG80 and MCM21 to stabilize them.<ref>PMID:10574768</ref> <ref>PMID:10632874</ref>
 
== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
The line below this paragraph, {{ABSTRACT_PUBMED_17050532}}, adds the Publication Abstract to the page
Check<jmol>
(as it appears on PubMed at http://www.pubmed.gov), where 17050532 is the PubMed ID number.
  <jmolCheckbox>
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ie/2iew_consurf.spt"</scriptWhenChecked>
{{ABSTRACT_PUBMED_17050532}}
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 
    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
2IEW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IEW OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2iew ConSurf].
 
<div style="clear:both"></div>
==Reference==
== References ==
Crystal structure of inositol phosphate multikinase 2 and implications for substrate specificity., Holmes W, Jogl G, J Biol Chem. 2006 Dec 8;281(49):38109-16. Epub 2006 Oct 18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17050532 17050532]
<references/>
[[Category: Inositol-polyphosphate multikinase]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Single protein]]
[[Category: Holmes W]]
[[Category: Holmes, W.]]
[[Category: Jogl G]]
[[Category: Jogl, G.]]
[[Category: Atp-grasp fold related]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:18:35 2008''

Latest revision as of 09:02, 21 February 2024

Crystal structure of Inositol Phosphate Multikinase Ipk2 from S. cerevisiae

2iew, resolution 2.00Å

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