1u73: Difference between revisions

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{{Seed}}
[[Image:1u73.png|left|200px]]


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==Crystal structure of a Dimeric Acidic Platelet Aggregation Inhibitor and Hypotensive Phospholipase A2 from Bothrops jararacussu==
The line below this paragraph, containing "STRUCTURE_1u73", creates the "Structure Box" on the page.
<StructureSection load='1u73' size='340' side='right'caption='[[1u73]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1u73]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bothrops_jararacussu Bothrops jararacussu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U73 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U73 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u73 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u73 OCA], [https://pdbe.org/1u73 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u73 RCSB], [https://www.ebi.ac.uk/pdbsum/1u73 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u73 ProSAT]</span></td></tr>
{{STRUCTURE_1u73| PDB=1u73 |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/PA2A_BOTJR PA2A_BOTJR] Snake venom phospholipase A2 (PLA2) that induces edema (activity that is inhibited by EDTA and dexamethasone), inhibits phospholipid-dependent collagen/ADP-induced platelet aggregation, possess hypotensive as well as anticoagulant activities. In addition, this enzyme shows bactericidal activity against E.coli and S.aureus. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.<ref>PMID:12167491</ref> <ref>PMID:15214498</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u7/1u73_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u73 ConSurf].
<div style="clear:both"></div>


===Crystal structure of a Dimeric Acidic Platelet Aggregation Inhibitor and Hypotensive Phospholipase A2 from Bothrops jararacussu===
==See Also==
 
*[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]]
 
== References ==
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{{ABSTRACT_PUBMED_15351695}}
 
==About this Structure==
1U73 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bothrops_jararacussu Bothrops jararacussu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U73 OCA].
 
==Reference==
Crystal structure of an acidic platelet aggregation inhibitor and hypotensive phospholipase A2 in the monomeric and dimeric states: insights into its oligomeric state., Magro AJ, Murakami MT, Marcussi S, Soares AM, Arni RK, Fontes MR, Biochem Biophys Res Commun. 2004 Oct 8;323(1):24-31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15351695 15351695]
[[Category: Bothrops jararacussu]]
[[Category: Bothrops jararacussu]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Arni, R K.]]
[[Category: Arni RK]]
[[Category: Fontes, M R.]]
[[Category: Fontes MR]]
[[Category: Magro, A J.]]
[[Category: Magro AJ]]
[[Category: Murakami, M T.]]
[[Category: Murakami MT]]
[[Category: Soares, A M.]]
[[Category: Soares AM]]
[[Category: Acidic phospholipase a2]]
[[Category: Bothrops jararacussu venom]]
[[Category: Crystal structure]]
[[Category: Dimeric]]
[[Category: Oligomeric state]]
[[Category: Platelet aggregation and hypotensive effect]]
[[Category: X-ray crystallography]]
 
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Retrieved from "https://proteopedia.org/1u73"