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New page: left|200px<br /><applet load="1l6h" size="450" color="white" frame="true" align="right" spinBox="true" caption="1l6h" /> '''Solution Structure of Plant nsLTP2 purified ...
 
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[[Image:1l6h.jpg|left|200px]]<br /><applet load="1l6h" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1l6h" />
'''Solution Structure of Plant nsLTP2 purified from Rice (oryza Sativa)'''<br />


==Overview==
==Solution Structure of Plant nsLTP2 purified from Rice (oryza Sativa)==
The three-dimensional structure of rice nonspecific lipid transfer protein, (nsLTP2) has been solved for the first time. The structure of nsLTP2 was, obtained using 813 distance constraints, 30 hydrogen bond constraints, and, 19 dihedral angle constraints. Fifteen of the 50 random simulated, annealing structures satisfied all of the constraints and possessed good, nonbonded contacts. The novel three-dimensional fold of rice nsLTP2, contains a triangular hydrophobic cavity formed by three prominent, helices. The four disulfide bonds required for stabilization of the nsLTP2, structure show a different pattern of cysteine pairing compared with, nsLTP1. The C terminus of the protein is very flexible and forms a cap, over the hydrophobic cavity. Molecular modeling studies suggested that the, hydrophobic cavity could accommodate large molecules with rigid, structures, such as sterols. The positively charged residues on the, molecular surface of nsLTP2 are structurally similar to other plant, defense proteins.
<StructureSection load='1l6h' size='340' side='right'caption='[[1l6h]]' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[1l6h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryza_sativa Oryza sativa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L6H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L6H FirstGlance]. <br>
1L6H is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Oryza_sativa Oryza sativa]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1L6H OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l6h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l6h OCA], [https://pdbe.org/1l6h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l6h RCSB], [https://www.ebi.ac.uk/pdbsum/1l6h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l6h ProSAT]</span></td></tr>
==Reference==
</table>
Solution structure of plant nonspecific lipid transfer protein-2 from rice (Oryza sativa)., Samuel D, Liu YJ, Cheng CS, Lyu PC, J Biol Chem. 2002 Sep 20;277(38):35267-73. Epub 2002 May 13. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12011089 12011089]
== Function ==
[https://www.uniprot.org/uniprot/NLTPX_ORYSJ NLTPX_ORYSJ] Transfer lipids across membranes. May play a role in plant defense or in the biosynthesis of cuticle layers.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l6/1l6h_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1l6h ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Oryza sativa]]
[[Category: Oryza sativa]]
[[Category: Single protein]]
[[Category: Lyu P-C]]
[[Category: Lyu, P.C.]]
[[Category: Samuel D]]
[[Category: Samuel, D.]]
[[Category: lipid transfer]]
[[Category: nsltp2]]
[[Category: plant ltp]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 20:19:00 2007''

Latest revision as of 08:06, 3 April 2024

Solution Structure of Plant nsLTP2 purified from Rice (oryza Sativa)

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