2e7p: Difference between revisions

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{{Seed}}
[[Image:2e7p.png|left|200px]]


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==Crystal structure of the holo form of glutaredoxin C1 from populus tremula x tremuloides==
The line below this paragraph, containing "STRUCTURE_2e7p", creates the "Structure Box" on the page.
<StructureSection load='2e7p' size='340' side='right'caption='[[2e7p]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2e7p]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Populus_tremula_x_Populus_tremuloides Populus tremula x Populus tremuloides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E7P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E7P FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene></td></tr>
{{STRUCTURE_2e7p|  PDB=2e7p  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e7p OCA], [https://pdbe.org/2e7p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e7p RCSB], [https://www.ebi.ac.uk/pdbsum/2e7p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e7p ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q5PSJ1_POPPZ Q5PSJ1_POPPZ]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e7/2e7p_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e7p ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
When expressed in Escherichia coli, cytosolic poplar glutaredoxin C1 (CGYC active site) exists as a dimeric iron-sulfur-containing holoprotein or as a monomeric apoprotein in solution. Analytical and spectroscopic studies of wild-type protein and site-directed variants and structural characterization of the holoprotein by using x-ray crystallography indicate that the holoprotein contains a subunit-bridging [2Fe-2S] cluster that is ligated by the catalytic cysteines of two glutaredoxins and the cysteines of two glutathiones. Mutagenesis data on a variety of poplar glutaredoxins suggest that the incorporation of an iron-sulfur cluster could be a general feature of plant glutaredoxins possessing a glycine adjacent to the catalytic cysteine. In light of these results, the possible involvement of plant glutaredoxins in oxidative stress sensing or iron-sulfur biosynthesis is discussed with respect to their intracellular localization.


===Crystal structure of the holo form of glutaredoxin C1 from populus tremula x tremuloides===
Functional, structural, and spectroscopic characterization of a glutathione-ligated [2Fe-2S] cluster in poplar glutaredoxin C1.,Rouhier N, Unno H, Bandyopadhyay S, Masip L, Kim SK, Hirasawa M, Gualberto JM, Lattard V, Kusunoki M, Knaff DB, Georgiou G, Hase T, Johnson MK, Jacquot JP Proc Natl Acad Sci U S A. 2007 May 1;104(18):7379-84. Epub 2007 Apr 25. PMID:17460036<ref>PMID:17460036</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
<!--
</div>
The line below this paragraph, {{ABSTRACT_PUBMED_17460036}}, adds the Publication Abstract to the page
<div class="pdbe-citations 2e7p" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 17460036 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_17460036}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Large Structures]]
2E7P is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Populus_tremula_x_populus_tremuloides Populus tremula x populus tremuloides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E7P OCA].
[[Category: Populus tremula x Populus tremuloides]]
 
[[Category: Aimoto S]]
==Reference==
[[Category: Hase T]]
Functional, structural, and spectroscopic characterization of a glutathione-ligated [2Fe-2S] cluster in poplar glutaredoxin C1., Rouhier N, Unno H, Bandyopadhyay S, Masip L, Kim SK, Hirasawa M, Gualberto JM, Lattard V, Kusunoki M, Knaff DB, Georgiou G, Hase T, Johnson MK, Jacquot JP, Proc Natl Acad Sci U S A. 2007 May 1;104(18):7379-84. Epub 2007 Apr 25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17460036 17460036]
[[Category: Jacquot JP]]
[[Category: Populus tremula x populus tremuloides]]
[[Category: Kawakami T]]
[[Category: Single protein]]
[[Category: Kusunoki M]]
[[Category: Aimoto, S.]]
[[Category: Rouhier N]]
[[Category: Hase, T.]]
[[Category: Takahashi T]]
[[Category: Jacquot, J P.]]
[[Category: Unno H]]
[[Category: Kawakami, T.]]
[[Category: Kusunoki, M.]]
[[Category: Rouhier, N.]]
[[Category: Takahashi, T.]]
[[Category: Unno, H.]]
[[Category: Electron transport]]
[[Category: Glutaredoxin]]
[[Category: Poplar]]
[[Category: Thioredoxin fold]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:04:05 2008''

Latest revision as of 07:57, 13 August 2026

Crystal structure of the holo form of glutaredoxin C1 from populus tremula x tremuloides

2e7p, resolution 2.10Å

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