1p9f: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
 
(8 intermediate revisions by the same user not shown)
Line 1: Line 1:
{{Seed}}
[[Image:1p9f.png|left|200px]]


<!--
==NMR Structure of Neurokinin B from DYANA==
The line below this paragraph, containing "STRUCTURE_1p9f", creates the "Structure Box" on the page.
<StructureSection load='1p9f' size='340' side='right'caption='[[1p9f]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1p9f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P9F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P9F FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p9f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p9f OCA], [https://pdbe.org/1p9f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p9f RCSB], [https://www.ebi.ac.uk/pdbsum/1p9f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p9f ProSAT]</span></td></tr>
{{STRUCTURE_1p9f|  PDB=1p9f  |  SCENE=  }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/TKNK_HUMAN TKNK_HUMAN] Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles (By similarity).
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Neurokinin B (NKB), a decapeptide of mammalian origin exhibits a variety of biological activities such as regulatory functions in reproduction, pre-eclampsia and neuroprotection in Alzheimer's disease. In order to gain insight into structure-function relationship, three-dimensional structure of NKB has been investigated using CD spectropolarimetry and two-dimensional proton nuclear magnetic resonance (2D 1H-NMR) spectroscopy in aqueous and membrane mimetic solvents. Unambiguous NMR assignments of resonances have been made with the aid of correlation spectroscopy (DQF-COSY and TOCSY) experiments and Nuclear Overhauser Effect Spectroscopy (NOESY) experiments. Distance constraints obtained from the NMR data have been used to generate a family of structures, which have been refined using restrained energy minimization and dynamics. Our data show that a helical structure is induced in NKB, in presence of perdeuterated dodecyl phosphocholine (DPC) micelles, a membrane model system. Further, the conformation adopted by NKB in presence of DPC micelles represents a structural motif typical of neurokinin-3 selective agonists.


===NMR Structure of Neurokinin B from DYANA===
Three dimensional structure of mammalian tachykinin peptide neurokinin B bound to lipid micelles.,Mantha AK, Chandrashekar IR, Baquer NZ, Cowsik SM J Biomol Struct Dyn. 2004 Oct;22(2):137-48. PMID:15317475<ref>PMID:15317475</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
<!--
</div>
The line below this paragraph, {{ABSTRACT_PUBMED_15317475}}, adds the Publication Abstract to the page
<div class="pdbe-citations 1p9f" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 15317475 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_15317475}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Homo sapiens]]
1P9F is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P9F OCA].
[[Category: Large Structures]]
 
[[Category: Baquer NZ]]
==Reference==
[[Category: Chandrashekar IR]]
Three dimensional structure of mammalian tachykinin peptide neurokinin B bound to lipid micelles., Mantha AK, Chandrashekar IR, Baquer NZ, Cowsik SM, J Biomol Struct Dyn. 2004 Oct;22(2):137-48. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15317475 15317475]
[[Category: Cowsik SM]]
[[Category: Single protein]]
[[Category: Mantha AK]]
[[Category: Baquer, N Z.]]
[[Category: Chandrashekar, I R.]]
[[Category: Cowsik, S M.]]
[[Category: Mantha, A K.]]
[[Category: Neuropeptide]]
[[Category: Protein]]
[[Category: Structures from dyana]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:45:43 2008''
Retrieved from "https://proteopedia.org/1p9f"