1yfq: Difference between revisions

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{{Seed}}
[[Image:1yfq.png|left|200px]]


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==High resolution S. cerevisiae Bub3 mitotic checkpoint protein==
The line below this paragraph, containing "STRUCTURE_1yfq", creates the "Structure Box" on the page.
<StructureSection load='1yfq' size='340' side='right'caption='[[1yfq]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1yfq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YFQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YFQ FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.1&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
{{STRUCTURE_1yfq|  PDB=1yfq  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yfq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yfq OCA], [https://pdbe.org/1yfq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yfq RCSB], [https://www.ebi.ac.uk/pdbsum/1yfq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yfq ProSAT]</span></td></tr>
 
</table>
===High resolution S. cerevisiae Bub3 mitotic checkpoint protein===
== Function ==
 
[https://www.uniprot.org/uniprot/BUB3_YEAST BUB3_YEAST] Required for cell cycle arrest in response to loss of microtubule function. Component of the spindle assembly checkpoint which is a feedback control that prevents cells with incompletely assembled spindles from leaving mitosis. Component of the mitotic checkpoint complex (MCC) which inhibits the ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) by preventing its activation by CDC20. The formation of a MAD1-BUB1-BUB3 complex seems to be required for the spindle checkpoint mechanism.<ref>PMID:15879521</ref>
 
== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
The line below this paragraph, {{ABSTRACT_PUBMED_15644329}}, adds the Publication Abstract to the page
Check<jmol>
(as it appears on PubMed at http://www.pubmed.gov), where 15644329 is the PubMed ID number.
  <jmolCheckbox>
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yf/1yfq_consurf.spt"</scriptWhenChecked>
{{ABSTRACT_PUBMED_15644329}}
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 
    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
1YFQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YFQ OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yfq ConSurf].
 
<div style="clear:both"></div>
==Reference==
== References ==
The 1.1-angstrom structure of the spindle checkpoint protein Bub3p reveals functional regions., Wilson DK, Cerna D, Chew E, J Biol Chem. 2005 Apr 8;280(14):13944-51. Epub 2005 Jan 11. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15644329 15644329]
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Single protein]]
[[Category: Cerna D]]
[[Category: Cerna, D.]]
[[Category: Chew E]]
[[Category: Chew, E.]]
[[Category: Wilson DK]]
[[Category: Wilson, D K.]]
[[Category: Wd repeat wd40 repeat beta transducin repeat all beta]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:57:09 2008''

Latest revision as of 08:57, 14 February 2024

High resolution S. cerevisiae Bub3 mitotic checkpoint protein

1yfq, resolution 1.10Å

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