2qsk: Difference between revisions

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{{Seed}}
[[Image:2qsk.png|left|200px]]


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==Atomic-resolution crystal structure of the Recombinant form of Scytovirin==
The line below this paragraph, containing "STRUCTURE_2qsk", creates the "Structure Box" on the page.
<StructureSection load='2qsk' size='340' side='right'caption='[[2qsk]], [[Resolution|resolution]] 1.00&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2qsk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Scytonema_varium Scytonema varium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QSK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QSK FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
{{STRUCTURE_2qsk|  PDB=2qsk  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qsk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qsk OCA], [https://pdbe.org/2qsk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qsk RCSB], [https://www.ebi.ac.uk/pdbsum/2qsk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qsk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SVN_SCYVA SVN_SCYVA] Has strong anti-HIV activity against T-tropic strains of HIV-1 and weaker activity against M-tropic strains of HIV-1. Inhibits HIV-1 fusion and infection of CD4 LTR beta-gal cells in vitro. Inhibits fusion of HIV infected CEM-SS cells with uninfected CEM-SS cells, and fusion of HIV-1 Env expressing HL2/3 cells with CD4 LTR beta-gal cells. Binds to HIV gp120, HIV gp160 and to a lesser extent HIV gp41. Binding to HIV gp120 is glycosylation dependent. Binds with high specificity to the tetrasaccharide Man-alpha-1,2-Man-alpha-1,6-Man-alpha-1,6-Man and also binds the higher-order oligosaccharides oligomannose 8 and oligomannose 9. Does not bind to monosaccharides, complex or hybrid N-linked oligosaccharides or chitin.<ref>PMID:12614152</ref> <ref>PMID:16647158</ref> <ref>PMID:17269926</ref> <ref>PMID:17434526</ref>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The crystal structures of the natural and recombinant antiviral lectin scytovirin (SVN) were solved by single-wavelength anomalous scattering and refined with data extending to 1.3 A and 1.0 A resolution, respectively. A molecule of SVN consists of a single chain 95 amino acids long, with an almost perfect sequence repeat that creates two very similar domains (RMS deviation 0.25 A for 40 pairs of Calpha atoms). The crystal structure differs significantly from a previously published NMR structure of the same protein, with the RMS deviations calculated separately for the N- and C-terminal domains of 5.3 A and 3.7 A, respectively, and a very different relationship between the two domains. In addition, the disulfide bonding pattern of the crystal structures differs from that described in the previously published mass spectrometry and NMR studies.


===Atomic-resolution crystal structure of the Recombinant form of Scytovirin===
Atomic-resolution crystal structure of the antiviral lectin scytovirin.,Moulaei T, Botos I, Ziolkowska NE, Bokesch HR, Krumpe LR, McKee TC, O'Keefe BR, Dauter Z, Wlodawer A Protein Sci. 2007 Dec;16(12):2756-60. Epub 2007 Oct 26. PMID:17965185<ref>PMID:17965185</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The line below this paragraph, {{ABSTRACT_PUBMED_17965185}}, adds the Publication Abstract to the page
<div class="pdbe-citations 2qsk" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 17965185 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_17965185}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Large Structures]]
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QSK OCA].
[[Category: Scytonema varium]]
 
[[Category: Botos I]]
==Reference==
[[Category: Dauter Z]]
Atomic-resolution crystal structure of the antiviral lectin scytovirin., Moulaei T, Botos I, Ziolkowska NE, Bokesch HR, Krumpe LR, McKee TC, O'Keefe BR, Dauter Z, Wlodawer A, Protein Sci. 2007 Dec;16(12):2756-60. Epub 2007 Oct 26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17965185 17965185]
[[Category: Moulaei T]]
[[Category: Botos, I.]]
[[Category: Wlodawer A]]
[[Category: Dauter, Z.]]
[[Category: Ziolkowska NE]]
[[Category: Moulaei, T.]]
[[Category: Wlodawer, A.]]
[[Category: Ziolkowska, N E.]]
[[Category: Lectin]]
[[Category: Sugar binding protein]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:24:56 2008''

Latest revision as of 11:40, 30 August 2023

Atomic-resolution crystal structure of the Recombinant form of Scytovirin

2qsk, resolution 1.00Å

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