2i53: Difference between revisions

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{{Seed}}
[[Image:2i53.png|left|200px]]


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==Crystal structure of Cyclin K==
The line below this paragraph, containing "STRUCTURE_2i53", creates the "Structure Box" on the page.
<StructureSection load='2i53' size='340' side='right'caption='[[2i53]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2i53]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I53 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I53 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
{{STRUCTURE_2i53| PDB=2i53 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i53 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i53 OCA], [https://pdbe.org/2i53 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i53 RCSB], [https://www.ebi.ac.uk/pdbsum/2i53 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i53 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CCNK_HUMAN CCNK_HUMAN] May play a role in transcriptional regulation. In vitro, is associated with a kinase activity toward both RNA polymerase II C-terminal domain and CDK2 (CAK).<ref>PMID:10574912</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i5/2i53_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2i53 ConSurf].
<div style="clear:both"></div>


===Crystal structure of Cyclin K===
==See Also==
 
*[[Cyclin 3D structures|Cyclin 3D structures]]
 
== References ==
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__TOC__
(as it appears on PubMed at http://www.pubmed.gov), where 17169370 is the PubMed ID number.
</StructureSection>
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{{ABSTRACT_PUBMED_17169370}}
 
==About this Structure==
2I53 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I53 OCA].
 
==Reference==
Crystal structure of human cyclin K, a positive regulator of cyclin-dependent kinase 9., Baek K, Brown RS, Birrane G, Ladias JA, J Mol Biol. 2007 Feb 16;366(2):563-73. Epub 2006 Nov 18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17169370 17169370]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Baek, K.]]
[[Category: Baek K]]
[[Category: Birrane, G.]]
[[Category: Birrane G]]
[[Category: Brown, R S.]]
[[Category: Brown RS]]
[[Category: Ladias, J A.A.]]
[[Category: Ladias JAA]]
[[Category: Cdk9]]
[[Category: Cell cycle]]
[[Category: Cyclin box]]
[[Category: Cyclin k]]
[[Category: P-tefb]]
[[Category: Positive transcription elongation factor]]
[[Category: Transcription]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:43:34 2008''

Latest revision as of 09:01, 21 February 2024

Crystal structure of Cyclin K

2i53, resolution 1.50Å

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