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{{Seed}}
[[Image:1qqg.png|left|200px]]


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==CRYSTAL STRUCTURE OF THE PH-PTB TARGETING REGION OF IRS-1==
The line below this paragraph, containing "STRUCTURE_1qqg", creates the "Structure Box" on the page.
<StructureSection load='1qqg' size='340' side='right'caption='[[1qqg]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1qqg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QQG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QQG FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qqg OCA], [https://pdbe.org/1qqg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qqg RCSB], [https://www.ebi.ac.uk/pdbsum/1qqg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qqg ProSAT]</span></td></tr>
{{STRUCTURE_1qqg|  PDB=1qqg  |  SCENE=  }}
</table>
 
== Disease ==
===CRYSTAL STRUCTURE OF THE PH-PTB TARGETING REGION OF IRS-1===
[https://www.uniprot.org/uniprot/IRS1_HUMAN IRS1_HUMAN] Polymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:[https://omim.org/entry/125853 125853].<ref>PMID:14707024</ref> <ref>PMID:8723689</ref> <ref>PMID:10206679</ref> <ref>PMID:12843189</ref> <ref>PMID:15590636</ref>
 
== Function ==
 
[https://www.uniprot.org/uniprot/IRS1_HUMAN IRS1_HUMAN] May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).<ref>PMID:16878150</ref> <ref>PMID:14707024</ref>
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== Evolutionary Conservation ==
The line below this paragraph, {{ABSTRACT_PUBMED_10411883}}, adds the Publication Abstract to the page
[[Image:Consurf_key_small.gif|200px|right]]
(as it appears on PubMed at http://www.pubmed.gov), where 10411883 is the PubMed ID number.
Check<jmol>
-->
  <jmolCheckbox>
{{ABSTRACT_PUBMED_10411883}}
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qq/1qqg_consurf.spt"</scriptWhenChecked>
 
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
==About this Structure==
    <text>to colour the structure by Evolutionary Conservation</text>
1QQG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QQG OCA].  
  </jmolCheckbox>
 
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qqg ConSurf].
==Reference==
<div style="clear:both"></div>
Crystal structure of the pleckstrin homology-phosphotyrosine binding (PH-PTB) targeting region of insulin receptor substrate 1., Dhe-Paganon S, Ottinger EA, Nolte RT, Eck MJ, Shoelson SE, Proc Natl Acad Sci U S A. 1999 Jul 20;96(15):8378-83. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10411883 10411883]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Dhe-Paganon, S.]]
[[Category: Dhe-Paganon S]]
[[Category: Shoelson, S E.]]
[[Category: Shoelson SE]]
[[Category: Beta-sandwhich]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:48:31 2008''

Latest revision as of 08:16, 14 February 2024

CRYSTAL STRUCTURE OF THE PH-PTB TARGETING REGION OF IRS-1

1qqg, resolution 2.30Å

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