1lqk: Difference between revisions
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New page: left|200px<br /><applet load="1lqk" size="450" color="white" frame="true" align="right" spinBox="true" caption="1lqk, resolution 1.35Å" /> '''High Resolution Stru... |
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== | ==High Resolution Structure of Fosfomycin Resistance Protein A (FosA)== | ||
<StructureSection load='1lqk' size='340' side='right'caption='[[1lqk]], [[Resolution|resolution]] 1.35Å' scene=''> | |||
== Structural highlights == | |||
== | <table><tr><td colspan='2'>[[1lqk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LQK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LQK FirstGlance]. <br> | ||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.35Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lqk OCA], [https://pdbe.org/1lqk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lqk RCSB], [https://www.ebi.ac.uk/pdbsum/1lqk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lqk ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/FOSA_PSEAE FOSA_PSEAE] Metalloglutathione transferase which confers resistance to fosfomycin by catalyzing the addition of glutathione to fosfomycin. | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lq/1lqk_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lqk ConSurf]. | |||
<div style="clear:both"></div> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Pseudomonas aeruginosa]] | [[Category: Pseudomonas aeruginosa]] | ||
[[Category: Armstrong RN]] | |||
[[Category: Armstrong | [[Category: Newcomer ME]] | ||
[[Category: Newcomer | [[Category: Pharris RE]] | ||
[[Category: Pharris | [[Category: Rife CL]] | ||
[[Category: Rife | |||
Latest revision as of 07:35, 14 February 2024
High Resolution Structure of Fosfomycin Resistance Protein A (FosA)
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