2j52: Difference between revisions

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{{Seed}}
[[Image:2j52.png|left|200px]]


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==Solution Structure of GB1 domain Protein G and low and high pressure.==
The line below this paragraph, containing "STRUCTURE_2j52", creates the "Structure Box" on the page.
<StructureSection load='2j52' size='340' side='right'caption='[[2j52]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2j52]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_sp. Streptococcus sp.]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J52 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J52 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j52 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j52 OCA], [https://pdbe.org/2j52 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j52 RCSB], [https://www.ebi.ac.uk/pdbsum/2j52 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j52 ProSAT]</span></td></tr>
{{STRUCTURE_2j52|  PDB=2j52  |  SCENE=  }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/SPG1_STRSG SPG1_STRSG] Binds to the constant Fc region of IgG with high affinity.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j5/2j52_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2j52 ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The solution structure of the GB1 domain of protein G at a pressure of 2 kbar is presented. The structure was calculated as a change from an energy-minimised low-pressure structure using (1)H chemical shifts. Two separate changes can be characterised: a compression/distortion, which is linear with pressure; and a stabilisation of an alternative folded state. On application of pressure, linear chemical shift changes reveal that the backbone structure changes by about 0.2 A root mean square, and is compressed by about 1% overall. The alpha-helix compresses, particularly at the C-terminal end, and moves toward the beta-sheet, while the beta-sheet is twisted, with the corners closest to the alpha-helix curling up towards it. The largest changes in structure are along the second beta-strand, which becomes more twisted. This strand is where the protein binds to IgG. Curved chemical shift changes with pressure indicate that high pressure also populates an alternative structure with a distortion towards the C-terminal end of the helix, which is likely to be caused by insertion of a water molecule. Proteins 2007. (c) 2007 Wiley-Liss, Inc.


===SOLUTION STRUCTURE OF GB1 DOMAIN PROTEIN G AND LOW AND HIGH PRESSURE.===
Pressure-induced changes in the solution structure of the GB1 domain of protein G.,Wilton DJ, Tunnicliffe RB, Kamatari YO, Akasaka K, Williamson MP Proteins. 2007 Dec 12;. PMID:18076052<ref>PMID:18076052</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The line below this paragraph, {{ABSTRACT_PUBMED_18076052}}, adds the Publication Abstract to the page
<div class="pdbe-citations 2j52" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 18076052 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_18076052}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Large Structures]]
2J52 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_sp. Streptococcus sp.]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J52 OCA].
[[Category: Streptococcus sp]]
 
[[Category: Akasaka K]]
==Reference==
[[Category: Kamatari YO]]
Pressure-induced changes in the solution structure of the GB1 domain of protein G., Wilton DJ, Tunnicliffe RB, Kamatari YO, Akasaka K, Williamson MP, Proteins. 2007 Dec 12;. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18076052 18076052]
[[Category: Tunnicliffe RB]]
[[Category: Single protein]]
[[Category: Williamson MP]]
[[Category: Streptococcus sp.]]
[[Category: Wilton DJ]]
[[Category: Akasaka, K.]]
[[Category: Kamatari, Y O.]]
[[Category: Tunnicliffe, R B.]]
[[Category: Williamson, M P.]]
[[Category: Wilton, D J.]]
[[Category: Cell wall]]
[[Category: Igg-binding protein]]
[[Category: Immunoglobulin]]
[[Category: Peptidoglycan-anchor]]
[[Category: Pressure]]
[[Category: Protein g]]
 
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Latest revision as of 05:35, 15 May 2024

Solution Structure of GB1 domain Protein G and low and high pressure.

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