2bcw: Difference between revisions

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{{Seed}}
[[Image:2bcw.png|left|200px]]


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==Coordinates of the N-terminal domain of ribosomal protein L11,C-terminal domain of ribosomal protein L7/L12 and a portion of the G' domain of elongation factor G, as fitted into cryo-em map of an Escherichia coli 70S*EF-G*GDP*fusidic acid complex==
The line below this paragraph, containing "STRUCTURE_2bcw", creates the "Structure Box" on the page.
<SX load='2bcw' size='340' side='right' viewer='molstar' caption='[[2bcw]], [[Resolution|resolution]] 11.20&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2bcw]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli], [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima] and [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BCW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BCW FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 11.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bcw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bcw OCA], [https://pdbe.org/2bcw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bcw RCSB], [https://www.ebi.ac.uk/pdbsum/2bcw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bcw ProSAT]</span></td></tr>
{{STRUCTURE_2bcw| PDB=2bcw |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/RL7_ECOLI RL7_ECOLI] Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation.[HAMAP-Rule:MF_00368]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bc/2bcw_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bcw ConSurf].
<div style="clear:both"></div>


===Coordinates of the N-terminal domain of ribosomal protein L11,C-terminal domain of ribosomal protein L7/L12 and a portion of the G' domain of elongation factor G, as fitted into cryo-em map of an Escherichia coli 70S*EF-G*GDP*fusidic acid complex===
==See Also==
 
*[[Elongation factor 3D structures|Elongation factor 3D structures]]
 
*[[Ribosomal protein L11 3D structures|Ribosomal protein L11 3D structures]]
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*[[Ribosomal protein L7/L12|Ribosomal protein L7/L12]]
The line below this paragraph, {{ABSTRACT_PUBMED_16337596}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16337596 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16337596}}
 
==About this Structure==
2BCW is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli], [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima] and [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BCW OCA].
 
==Reference==
Interaction of the G' domain of elongation factor G and the C-terminal domain of ribosomal protein L7/L12 during translocation as revealed by cryo-EM., Datta PP, Sharma MR, Qi L, Frank J, Agrawal RK, Mol Cell. 2005 Dec 9;20(5):723-31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16337596 16337596]
 
A detailed view of a ribosomal active site: the structure of the L11-RNA complex., Wimberly BT, Guymon R, McCutcheon JP, White SW, Ramakrishnan V, Cell. 1999 May 14;97(4):491-502. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10338213 10338213]
 
Structure of the C-terminal domain of the ribosomal protein L7/L12 from Escherichia coli at 1.7 A., Leijonmarck M, Liljas A, J Mol Biol. 1987 Jun 5;195(3):555-79. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/3309338 3309338]
 
Three-dimensional structure of the ribosomal translocase: elongation factor G from Thermus thermophilus., AEvarsson A, Brazhnikov E, Garber M, Zheltonosova J, Chirgadze Y, al-Karadaghi S, Svensson LA, Liljas A, EMBO J. 1994 Aug 15;13(16):3669-77. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8070397 8070397]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Protein complex]]
[[Category: Large Structures]]
[[Category: Thermotoga maritima]]
[[Category: Thermotoga maritima]]
[[Category: Thermus thermophilus]]
[[Category: Thermus thermophilus]]
[[Category: Agrawal, R K.]]
[[Category: Agrawal RK]]
[[Category: Datta, P P.]]
[[Category: Datta PP]]
[[Category: Frank, J.]]
[[Category: Frank J]]
[[Category: Qi, L.]]
[[Category: Qi L]]
[[Category: Sharma, M R.]]
[[Category: Sharma MR]]
[[Category: Components involved in interaction between ef-g and l7/l12 stalk base of the ribosome]]
 
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Retrieved from "https://proteopedia.org/2bcw"