2avt: Difference between revisions

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{{Seed}}
[[Image:2avt.png|left|200px]]


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==Crystal structure of the beta subunit from DNA polymerase of Streptococcus pyogenes==
The line below this paragraph, containing "STRUCTURE_2avt", creates the "Structure Box" on the page.
<StructureSection load='2avt' size='340' side='right'caption='[[2avt]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2avt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AVT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AVT FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2avt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2avt OCA], [https://pdbe.org/2avt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2avt RCSB], [https://www.ebi.ac.uk/pdbsum/2avt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2avt ProSAT]</span></td></tr>
{{STRUCTURE_2avt| PDB=2avt |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q9EVR1_STRPY Q9EVR1_STRPY] Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.[ARBA:ARBA00002266]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/av/2avt_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2avt ConSurf].
<div style="clear:both"></div>


===Crystal structure of the beta subunit from DNA polymerase of Streptococcus pyogenes===
==See Also==
 
*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
 
__TOC__
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_16403212}}, adds the Publication Abstract to the page
[[Category: Large Structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 16403212 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16403212}}
 
==About this Structure==
2AVT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AVT OCA].
 
==Reference==
Crystal structure of a DNA polymerase sliding clamp from a Gram-positive bacterium., Argiriadi MA, Goedken ER, Bruck I, O'Donnell M, Kuriyan J, BMC Struct Biol. 2006 Jan 10;6:2. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16403212 16403212]
[[Category: Single protein]]
[[Category: Streptococcus pyogenes]]
[[Category: Streptococcus pyogenes]]
[[Category: Argiriadi, M A.]]
[[Category: Argiriadi MA]]
[[Category: Bruck, I.]]
[[Category: Bruck I]]
[[Category: Goedken, E R.]]
[[Category: Goedken ER]]
[[Category: Kuriyan, J.]]
[[Category: Kuriyan J]]
[[Category: Donnell, M O.]]
[[Category: O'donnell M]]
[[Category: Beta clamp]]
[[Category: Polymerase]]
[[Category: Replication]]
[[Category: Sliding clamp]]
 
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Retrieved from "https://proteopedia.org/2avt"