1mvh: Difference between revisions

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{{Seed}}
[[Image:1mvh.png|left|200px]]


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==structure of the SET domain histone lysine methyltransferase Clr4==
The line below this paragraph, containing "STRUCTURE_1mvh", creates the "Structure Box" on the page.
<StructureSection load='1mvh' size='340' side='right'caption='[[1mvh]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1mvh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MVH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MVH FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_1mvh|  PDB=1mvh  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mvh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mvh OCA], [https://pdbe.org/1mvh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mvh RCSB], [https://www.ebi.ac.uk/pdbsum/1mvh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mvh ProSAT]</span></td></tr>
 
</table>
===structure of the SET domain histone lysine methyltransferase Clr4===
== Function ==
 
[https://www.uniprot.org/uniprot/CLR4_SCHPO CLR4_SCHPO] Histone methyltransferase. Catalytic component of the rik1-associated E3 ubiquitin ligase complex that shows ubiquitin ligase activity and is required for histone H3K9 methylation. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting swi6/HP1 to methylated histones which leads to transcriptional silencing within centromeric heterochromatin, telomeric regions and at the silent mating-type loci.<ref>PMID:16024659</ref> <ref>PMID:8138176</ref>
 
== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
The line below this paragraph, {{ABSTRACT_PUBMED_12389037}}, adds the Publication Abstract to the page
Check<jmol>
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  <jmolCheckbox>
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mv/1mvh_consurf.spt"</scriptWhenChecked>
{{ABSTRACT_PUBMED_12389037}}
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 
    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
1MVH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MVH OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mvh ConSurf].
 
<div style="clear:both"></div>
==Reference==
== References ==
Structure of the SET domain histone lysine methyltransferase Clr4., Min J, Zhang X, Cheng X, Grewal SI, Xu RM, Nat Struct Biol. 2002 Nov;9(11):828-32. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12389037 12389037]
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Schizosaccharomyces pombe]]
[[Category: Schizosaccharomyces pombe]]
[[Category: Single protein]]
[[Category: Cheng XD]]
[[Category: Cheng, X D.]]
[[Category: Grewal SIS]]
[[Category: Grewal, S I.S.]]
[[Category: Min JR]]
[[Category: Min, J R.]]
[[Category: Xu R-M]]
[[Category: Xu, R M.]]
[[Category: Zhang X]]
[[Category: Zhang, X.]]
[[Category: Clr4]]
[[Category: Lysine methyltransferase]]
[[Category: Set-domain]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:20:59 2008''

Latest revision as of 07:49, 14 February 2024

structure of the SET domain histone lysine methyltransferase Clr4

1mvh, resolution 2.30Å

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