2geb: Difference between revisions

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{{Seed}}
[[Image:2geb.png|left|200px]]


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==Crystal structure of the Thermoanaerobacter tengcongensis hypoxanthine-guanine phosphoribosyltransferase L160I mutant: insights into the inhibitor design==
The line below this paragraph, containing "STRUCTURE_2geb", creates the "Structure Box" on the page.
<StructureSection load='2geb' size='340' side='right'caption='[[2geb]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2geb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Caldanaerobacter_subterraneus_subsp._tengcongensis Caldanaerobacter subterraneus subsp. tengcongensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GEB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GEB FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
{{STRUCTURE_2geb|  PDB=2geb |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2geb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2geb OCA], [https://pdbe.org/2geb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2geb RCSB], [https://www.ebi.ac.uk/pdbsum/2geb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2geb ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q8R7L0_CALS4 Q8R7L0_CALS4]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ge/2geb_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2geb ConSurf].
<div style="clear:both"></div>


===Crystal structure of the Thermoanaerobacter tengcongensis hypoxanthine-guanine phosphoribosyltransferase L160I mutant: insights into the inhibitor design===
==See Also==
 
*[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]]
 
__TOC__
<!--
</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_17662107}}, adds the Publication Abstract to the page
[[Category: Caldanaerobacter subterraneus subsp. tengcongensis]]
(as it appears on PubMed at http://www.pubmed.gov), where 17662107 is the PubMed ID number.
[[Category: Large Structures]]
-->
[[Category: Chen Q]]
{{ABSTRACT_PUBMED_17662107}}
[[Category: Luo M]]
 
==About this Structure==
2GEB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermoanaerobacter_tengcongensis Thermoanaerobacter tengcongensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GEB OCA].
 
==Reference==
Crystal structure of Thermoanaerobacter tengcongensis hypoxanthine-guanine phosphoribosyl transferase L160I mutant--insights into inhibitor design., Chen Q, You D, Liang Y, Su X, Gu X, Luo M, Zheng X, FEBS J. 2007 Sep;274(17):4408-15. Epub 2007 Jul 27. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17662107 17662107]
[[Category: Hypoxanthine phosphoribosyltransferase]]
[[Category: Single protein]]
[[Category: Thermoanaerobacter tengcongensis]]
[[Category: Chen, Q.]]
[[Category: Luo, M.]]
[[Category: Hgprt]]
[[Category: Inhibitor design]]
[[Category: Mutant]]
[[Category: Selectivity]]
[[Category: Transferase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:23:32 2008''

Latest revision as of 09:27, 14 February 2024

Crystal structure of the Thermoanaerobacter tengcongensis hypoxanthine-guanine phosphoribosyltransferase L160I mutant: insights into the inhibitor design

2geb, resolution 1.70Å

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