1m3c: Difference between revisions
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New page: left|200px<br /><applet load="1m3c" size="450" color="white" frame="true" align="right" spinBox="true" caption="1m3c" /> '''Solution structure of a circular form of the... |
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== | ==Solution structure of a circular form of the N-terminal SH3 domain (E132C, E133G, R191G mutant) from oncogene protein c-Crk== | ||
<StructureSection load='1m3c' size='340' side='right'caption='[[1m3c]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1m3c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M3C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M3C FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m3c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m3c OCA], [https://pdbe.org/1m3c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m3c RCSB], [https://www.ebi.ac.uk/pdbsum/1m3c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m3c ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/CRK_MOUSE CRK_MOUSE] The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling. | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m3/1m3c_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m3c ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | |||
*[[Adapter molecule crk 3D structures|Adapter molecule crk 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Camarero JA]] | |||
[[Category: Camarero | [[Category: Fushman D]] | ||
[[Category: Fushman | [[Category: Hall JB]] | ||
[[Category: Hall | [[Category: Schumann FH]] | ||
[[Category: Schumann | [[Category: Tayakuniyil PP]] | ||
[[Category: Tayakuniyil | [[Category: Varadan R]] | ||
[[Category: Varadan | |||
Latest revision as of 08:37, 6 November 2024
Solution structure of a circular form of the N-terminal SH3 domain (E132C, E133G, R191G mutant) from oncogene protein c-Crk
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