1ui6: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
 
(11 intermediate revisions by the same user not shown)
Line 1: Line 1:
{{Seed}}
[[Image:1ui6.png|left|200px]]


<!--
==Crystal structure of gamma-butyrolactone receptor (ArpA-like protein)==
The line below this paragraph, containing "STRUCTURE_1ui6", creates the "Structure Box" on the page.
<StructureSection load='1ui6' size='340' side='right'caption='[[1ui6]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1ui6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_coelicolor_A3(2) Streptomyces coelicolor A3(2)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UI6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UI6 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ui6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ui6 OCA], [https://pdbe.org/1ui6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ui6 RCSB], [https://www.ebi.ac.uk/pdbsum/1ui6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ui6 ProSAT]</span></td></tr>
{{STRUCTURE_1ui6|  PDB=1ui6  |  SCENE=  }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/O66122_STRCH O66122_STRCH]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ui/1ui6_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ui6 ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The gamma-butyrolactone-type autoregulator/receptor systems in the Gram-positive bacterial genus Streptomyces regulate morphological differentiation or antibiotic production, or both. The autoregulator receptors act as DNA-binding proteins, and on binding their cognate ligands (gamma-butyrolactones) they are released from the DNA, thus serving as repressors. The crystal structure of CprB in Streptomyces coelicolor A3(2), a homologue of the A-factor-receptor protein, ArpA, in Streptomyces griseus, was determined. The overall structure of CprB shows that the gamma-butyrolactone receptors belong to the TetR family. CprB is composed of two domains, a DNA-binding domain and a regulatory domain. The regulatory domain contains a hydrophobic cavity, which probably serves as a ligand-binding pocket. On the basis of the crystal structure of CprB and on the analogy of the characteristics of ligand-TetR binding, the binding of gamma-butyrolactones to the regulatory domain of the receptors is supposed to induce the relocation of the DNA-binding domain through conformational changes of residues located between the ligand-binding site and the DNA-binding domain, which would result in the dissociation of the receptors from their target DNA.


===Crystal structure of gamma-butyrolactone receptor (ArpA-like protein)===
Crystal structure of a gamma-butyrolactone autoregulator receptor protein in Streptomyces coelicolor A3(2).,Natsume R, Ohnishi Y, Senda T, Horinouchi S J Mol Biol. 2004 Feb 13;336(2):409-19. PMID:14757054<ref>PMID:14757054</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
<!--
</div>
The line below this paragraph, {{ABSTRACT_PUBMED_14757054}}, adds the Publication Abstract to the page
<div class="pdbe-citations 1ui6" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 14757054 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_14757054}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Large Structures]]
1UI6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_coelicolor Streptomyces coelicolor]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UI6 OCA].
[[Category: Horinouchi S]]
 
[[Category: Natsume R]]
==Reference==
[[Category: Senda T]]
Crystal structure of a gamma-butyrolactone autoregulator receptor protein in Streptomyces coelicolor A3(2)., Natsume R, Ohnishi Y, Senda T, Horinouchi S, J Mol Biol. 2004 Feb 13;336(2):409-19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14757054 14757054]
[[Category: Single protein]]
[[Category: Streptomyces coelicolor]]
[[Category: Horinouchi, S.]]
[[Category: Natsume, R.]]
[[Category: Senda, T.]]
[[Category: Alpha-helix bundle]]
[[Category: Helix-turn-helix]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:03:32 2008''

Latest revision as of 08:51, 6 November 2024

Crystal structure of gamma-butyrolactone receptor (ArpA-like protein)

1ui6, resolution 2.40Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=1ui6&oldid=4255562"