2hr1: Difference between revisions

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{{Seed}}
[[Image:2hr1.png|left|200px]]


<!--
==Ternary structure of WT M.HhaI C5-Cytosine DNA methyltransferase with unmodified DNA and AdoHcy==
The line below this paragraph, containing "STRUCTURE_2hr1", creates the "Structure Box" on the page.
<StructureSection load='2hr1' size='340' side='right'caption='[[2hr1]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2hr1]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_parahaemolyticus Haemophilus parahaemolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HR1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HR1 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.96&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
{{STRUCTURE_2hr1| PDB=2hr1 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hr1 OCA], [https://pdbe.org/2hr1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hr1 RCSB], [https://www.ebi.ac.uk/pdbsum/2hr1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hr1 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MTH1_HAEPH MTH1_HAEPH] This methylase recognizes the double-stranded sequence GCGC, causes specific methylation on C-2 on both strands, and protects the DNA from cleavage by the HhaI endonuclease.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hr/2hr1_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hr1 ConSurf].
<div style="clear:both"></div>


===Ternary structure of WT M.HhaI C5-Cytosine DNA methyltransferase with unmodified DNA and AdoHcy===
==See Also==
 
*[[DNA methyltransferase 3D structures|DNA methyltransferase 3D structures]]
 
__TOC__
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_16926025}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 16926025 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_16926025}}
 
==About this Structure==
2HR1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Haemophilus_parahaemolyticus Haemophilus parahaemolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HR1 OCA].
 
==Reference==
The role of Arg165 towards base flipping, base stabilization and catalysis in M.HhaI., Shieh FK, Youngblood B, Reich NO, J Mol Biol. 2006 Sep 22;362(3):516-27. Epub 2006 Jul 22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16926025 16926025]
[[Category: Deleted entry]]
[[Category: Haemophilus parahaemolyticus]]
[[Category: Haemophilus parahaemolyticus]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Shieh, F.]]
[[Category: Shieh F]]
[[Category: High resolution]]
[[Category: M hhai]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:20:16 2008''

Latest revision as of 09:34, 14 February 2024

Ternary structure of WT M.HhaI C5-Cytosine DNA methyltransferase with unmodified DNA and AdoHcy

2hr1, resolution 1.96Å

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