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New page: left|200px<br /><applet load="1mvp" size="450" color="white" frame="true" align="right" spinBox="true" caption="1mvp, resolution 2.2Å" /> '''STRUCTURAL STUDIES OF...
 
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[[Image:1mvp.gif|left|200px]]<br /><applet load="1mvp" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1mvp, resolution 2.2&Aring;" />
'''STRUCTURAL STUDIES OF THE RETROVIRAL PROTEINASE FROM AVIAN MYELOBLASTOSIS ASSOCIATED VIRUS'''<br />


==Overview==
==STRUCTURAL STUDIES OF THE RETROVIRAL PROTEINASE FROM AVIAN MYELOBLASTOSIS ASSOCIATED VIRUS==
The structure of the retroviral proteinase from avian myeloblastosis, associated virus (MAV) has been determined and refined at 2.2 A, resolution. This structure is compared with those of homologous, proteinases from Rous sarcoma virus (RSV) and human immunodeficiency type, 1 virus (HIV). Through comparison with the structure of a, proteinase-inhibitor complex from HIV, a model of a complex between MAV, proteinase and a peptide substrate has been generated. Examination of this, model suggests structural basis for the diverse specifications of viral, proteinases.
<StructureSection load='1mvp' size='340' side='right'caption='[[1mvp]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[1mvp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Avian_myeloblastosis-associated_virus Avian myeloblastosis-associated virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MVP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MVP FirstGlance]. <br>
1MVP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Avian_myeloblastosis_associated_virus Avian myeloblastosis associated virus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1MVP OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mvp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mvp OCA], [https://pdbe.org/1mvp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mvp RCSB], [https://www.ebi.ac.uk/pdbsum/1mvp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mvp ProSAT]</span></td></tr>
==Reference==
</table>
Structural studies of the retroviral proteinase from avian myeloblastosis associated virus., Ohlendorf DH, Foundling SI, Wendoloski JJ, Sedlacek J, Strop P, Salemme FR, Proteins. 1992 Nov;14(3):382-91. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=1332025 1332025]
== Function ==
[[Category: Avian myeloblastosis associated virus]]
[https://www.uniprot.org/uniprot/GAG_AVIMA GAG_AVIMA] Specifically liberates the five major structural proteins from the common gag precursor, as well as reverse transcriptase and integrase from the gag-pol precursor.
[[Category: Single protein]]
== Evolutionary Conservation ==
[[Category: Foundling, S.I.]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: Ohlendorf, D.H.]]
Check<jmol>
[[Category: Salemme, F.R.]]
  <jmolCheckbox>
[[Category: hydrolase(aspartic proteinase)]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mv/1mvp_consurf.spt"</scriptWhenChecked>
 
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 21:44:24 2007''
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mvp ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Avian myeloblastosis-associated virus]]
[[Category: Large Structures]]
[[Category: Foundling SI]]
[[Category: Ohlendorf DH]]
[[Category: Salemme FR]]
Retrieved from "https://proteopedia.org/1mvp"