2jqc: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
 
(9 intermediate revisions by the same user not shown)
Line 1: Line 1:
{{Seed}}
[[Image:2jqc.png|left|200px]]


<!--
==A L-amino acid mutant of a D-amino acid containing conopeptide==
The line below this paragraph, containing "STRUCTURE_2jqc", creates the "Structure Box" on the page.
<StructureSection load='2jqc' size='340' side='right'caption='[[2jqc]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2jqc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JQC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JQC FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>
{{STRUCTURE_2jqc|  PDB=2jqc  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jqc OCA], [https://pdbe.org/2jqc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jqc RCSB], [https://www.ebi.ac.uk/pdbsum/2jqc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jqc ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/COMA_CONMR COMA_CONMR] May act as a neurotoxin.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Cone snails, a group of gastropod animals that inhabit tropical seas, are capable of producing a mixture of peptide neurotoxins, namely conotoxins, for defense and predation. Conotoxins are mainly disulfide-rich short peptides that act on different ion channels, neurotransmitter receptors, or transporters in the nervous system. They exhibit highly diverse compositions, structures, and biological functions. In this work, a novel Cys-free 15-residue conopeptide from Conus marmoreus was purified and designated as conomarphin. Conomarphin is unique because of its D-configuration Phe at the third residue from the C-terminus, which was identified using HPLC by comparing native conomarphin fragments and the corresponding synthetic peptides cleaved by different proteases. Surprisingly, the cDNA-encoded precursor of conomarphin was found to share the conserved signal peptide with other M-superfamily conotoxins, clearly indicating that conomarphin should belong to the M-superfamily, although conomarphin shares no homology with other six-Cys-containing M-superfamily conotoxins. Furthermore, NMR spectroscopy experiments established that conomarphin adopts a well-defined structure in solution, with a tight loop in the middle of the peptide and a short 3(10)-helix at the C-terminus. By contrast, no loop in L-Phe13-conomarphin was found, which suggests that D-Phe13 is essential for the structure of conomarphin. In conclusion, conomarphin may represent a new conotoxin family, whose biological activity remains to be identified.


===A L-amino acid mutant of a D-amino acid containing conopeptide===
Purification and structural characterization of a D-amino acid-containing conopeptide, conomarphin, from Conus marmoreus.,Han Y, Huang F, Jiang H, Liu L, Wang Q, Wang Y, Shao X, Chi C, Du W, Wang C FEBS J. 2008 May;275(9):1976-87. Epub 2008 Mar 18. PMID:18355315<ref>PMID:18355315</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
<!--
</div>
The line below this paragraph, {{ABSTRACT_PUBMED_18355315}}, adds the Publication Abstract to the page
<div class="pdbe-citations 2jqc" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 18355315 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_18355315}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Large Structures]]
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JQC OCA].
[[Category: Synthetic construct]]
 
[[Category: Chi C]]
==Reference==
[[Category: Du W]]
Purification and structural characterization of a d-amino acid-containing conopeptide, conomarphin, from Conus marmoreus., Han Y, Huang F, Jiang H, Liu L, Wang Q, Wang Y, Shao X, Chi C, Du W, Wang C, FEBS J. 2008 Mar 18;. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18355315 18355315]
[[Category: Han Y]]
[[Category: Chi, C.]]
[[Category: Huang F]]
[[Category: Du, W.]]
[[Category: Wang C]]
[[Category: Han, Y.]]
[[Category: Huang, F.]]
[[Category: Wang, C.]]
[[Category: M cono-toxin]]
[[Category: Mr12]]
[[Category: Nmr solution structure]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:51:09 2008''
Retrieved from "https://proteopedia.org/2jqc"