2es5: Difference between revisions

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{{Seed}}
[[Image:2es5.png|left|200px]]


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==Structure of the SRE RNA==
The line below this paragraph, containing "STRUCTURE_2es5", creates the "Structure Box" on the page.
<StructureSection load='2es5' size='340' side='right'caption='[[2es5]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2es5]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ES5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ES5 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2es5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2es5 OCA], [https://pdbe.org/2es5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2es5 RCSB], [https://www.ebi.ac.uk/pdbsum/2es5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2es5 ProSAT]</span></td></tr>
{{STRUCTURE_2es5|  PDB=2es5  |  SCENE=  }}
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Although the abundant sterile alpha motif (SAM) domain was originally classified as a protein-protein interaction domain, it has recently been shown that certain SAM domains have the ability to bind RNA, defining a new type of post-transcriptional gene regulator. To further understand the function of SAM-RNA recognition, we determined the solution structures of the SAM domain of the Saccharomyces cerevisiae Vts1p (Vts1p-SAM) and the Smaug response element (SRE) stem-loop RNA as a complex and in isolation. The structures show that Vts1p-SAM recognizes predominantly the shape of the SRE rather than its sequence, with the exception of a G located at the tip of the pentaloop. Using microarray gene profiling, we identified several genes in S. cerevisiae that seem to be regulated by Vts1p and contain one or more copies of the SRE.


===Structure of the SRE RNA===
Shape-specific recognition in the structure of the Vts1p SAM domain with RNA.,Oberstrass FC, Lee A, Stefl R, Janis M, Chanfreau G, Allain FH Nat Struct Mol Biol. 2006 Feb;13(2):160-7. Epub 2006 Jan 22. PMID:16429156<ref>PMID:16429156</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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(as it appears on PubMed at http://www.pubmed.gov), where 16429156 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_16429156}}
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</StructureSection>
==About this Structure==
[[Category: Large Structures]]
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ES5 OCA].
[[Category: Allain FHT]]
 
==Reference==
Shape-specific recognition in the structure of the Vts1p SAM domain with RNA., Oberstrass FC, Lee A, Stefl R, Janis M, Chanfreau G, Allain FH, Nat Struct Mol Biol. 2006 Feb;13(2):160-7. Epub 2006 Jan 22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16429156 16429156]
[[Category: Allain, F H.T.]]
[[Category: Pentaloop]]
[[Category: Rna structure]]
[[Category: Stem-loop]]
 
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