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New page: left|200px<br /><applet load="1n4y" size="450" color="white" frame="true" align="right" spinBox="true" caption="1n4y" /> '''REFINED STRUCTURE OF KISTRIN'''<br /> ==Ove...
 
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[[Image:1n4y.gif|left|200px]]<br /><applet load="1n4y" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1n4y" />
'''REFINED STRUCTURE OF KISTRIN'''<br />


==Overview==
==REFINED STRUCTURE OF KISTRIN==
The structure of kistrin, which is a member of a homologous family of, glycoprotein IIb-IIIa (GP IIb-IIIa) antagonists and potent protein, inhibitors of platelet aggregation, has been determined by two-dimensional, nuclear magnetic resonance (NMR) spectroscopy. The 68-residue protein, consists of a series of tightly packed loops held together by six, disulfide bonds and has almost no regular secondary structure. Kistrin has, an Arg-Gly-Asp (RGD) adhesion site recognition sequence important for, binding to GP IIb-IIIa that is located at the apex of a long loop across, the surface of the protein.
<StructureSection load='1n4y' size='340' side='right'caption='[[1n4y]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1n4y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Calloselasma_rhodostoma Calloselasma rhodostoma]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1kst 1kst]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N4Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N4Y FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n4y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n4y OCA], [https://pdbe.org/1n4y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n4y RCSB], [https://www.ebi.ac.uk/pdbsum/1n4y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n4y ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/VM2RH_CALRH VM2RH_CALRH] Metalloproteinase rhodostoxin: snake venom metalloproteinase that impairs hemostasis in the envenomed animal (By similarity). Disintegrin rhodostomin: inhibit platelet aggregation induced by ADP, thrombin, platelet-activating factor and collagen. Acts by inhibiting fibrinogen interaction with platelet receptors GPIIb/GPIIIa (ITGA2B/ITGB3).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n4/1n4y_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n4y ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
1N4Y is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Calloselasma_rhodostoma Calloselasma rhodostoma]. This structure superseeds the now removed PDB entry 1KST. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1N4Y OCA].
*[[Disintegrin|Disintegrin]]
 
__TOC__
==Reference==
</StructureSection>
Solution structure of kistrin, a potent platelet aggregation inhibitor and GP IIb-IIIa antagonist., Adler M, Lazarus RA, Dennis MS, Wagner G, Science. 1991 Jul 26;253(5018):445-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=1862345 1862345]
[[Category: Calloselasma rhodostoma]]
[[Category: Calloselasma rhodostoma]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Dennis, M.S.]]
[[Category: Dennis MS]]
[[Category: Krane, J.]]
[[Category: Krane J]]
[[Category: Krezel, A.M.]]
[[Category: Krezel AM]]
[[Category: Lazarus, R.A.]]
[[Category: Lazarus RA]]
[[Category: Wagner, G.]]
[[Category: Wagner G]]
[[Category: beta]]
[[Category: blood coagulation]]
[[Category: rgd]]
[[Category: venom]]
 
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Retrieved from "https://proteopedia.org/1n4y"